S-(+)-CBPGMF: C8H11NO4
MW: 185.17
A structurally new group I mGluR antagonist.

S-(+)-CBPG

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Synonym: S-(+)-2-(3'-Carboxybicyclo[1.1.1]pentyl)glycine; UPF 596
Application: A structurally new group I mGluR antagonist
Molecular Weight: 185.17
Molecular Formula: C8H11NO4
* Refer to Certificate of Analysis for lot specific data (including water content).

S-(+)-CBPG is a potent and selective, structurally new group I metabotropic glutamate receptor (mGluR) antagonist.


References

1. Pellicciari, R., et al., 1996. (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. Journal of medicinal chemistry. 39(15): 2874-6. PMID: 8709120
2. Moroni, F., et al., 1998. Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex. European journal of pharmacology. 347(2-3): 189-95. PMID: 9653880
3. Pellicciari, R., et al., 1999. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets. Current opinion in chemical biology. 3(4): 433-40. PMID: 10419848
4. Mannaioni, G., et al., 1999. Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 38(7): 917-26. PMID: 10428410
5. Schoepp, D D., et al., 1999. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 38(10): 1431-76. PMID: 10530808
6. Pellegrini-Giampietro, D E., et al., 1999. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. Neuropharmacology. 38(10): 1607-19. PMID: 10530822
7. Pellegrini-Giampietro, D E., et al., 1999. 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. The European journal of neuroscience. 11(10): 3637-47. PMID: 10564371

Physical State :
Solid
Solubility :
Soluble in water or DMSO.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5311040
SMILES :
C1C2(CC1(C2)C(=O)O)[[email protected]@H](C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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