Ruxolitinib PhosphateA JAK1/JAK2 inhibitor

Ruxolitinib Phosphate (CAS 1092939-17-7)

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Synonym: Jakafi; (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate
Application: A JAK1/JAK2 inhibitor
CAS Number: 1092939-17-7
Molecular Weight: 404.36
Molecular Formula: C17H18N6•H3O4P
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib (sc-364729). Mouse models have shown it to be a potent and selective Janus kinase (JAK1, IC50 = 5.9 nM and JAK2, IC50 = 5.7 nM) inhibitor. Ruxolitinib has also been shown to suppress interleukin-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM). Ruxolitinib significantly reduced splenomegaly and circulating levels of inflammatory cytokines and selectively eliminated neoplastic cells in mouse models of JAK2V617F+ myeloproliferative neoplasm, prolonging their survival without myelosuppressive or immunosuppressive effects.

Further studies of Ruxolitinib have demonstrated its ability to inhibit phosphorylated signal transducer and activator of transcription 3 (STAT3)

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25127112
SMILES :
C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

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Certificate of Analysis

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