Ruxolitinib (INCB018424) is a JAK inhibitor of JAK1 (IC50 = 2.7 nM), JAK2 (IC50 = 4.5 nM), and JAK3 (IC50 = 322 nM). JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to activate the signaling of certain growth factor receptors and cytokines.
Soluble in DMSO (61 mg/ml at 25 °C), ethanol (15 mg/ml) with warming, DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and methanol.
Puo essere utilizzato per malati di policitemia vera?
Asked by: francesco
Grazie per la domanda. Tutti i reagenti chimici e gli anticorpi offerti dalla Santa Cruz Biotechnology, Inc. sono forniti solo per ricerca di laboratorio in vitro (in-vitro RUO). I prodotti non sono destinati ad uso diagnostico o terapeutico e non devono essere utilizzati su animali o persone.
Thank you for your question. All chemicals and antibodies offered by Santa Cruz Biotechnology, Inc. are supplied for laboratory in-vitro research use only (in-vitro RUO). The products are not intended for diagnostic or therapeutic use and must not be applied to animals or humans.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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