Ruthenium redA voltage-sensitive calcium channel inhibitor

Ruthenium red (CAS 11103-72-3)

Ruthenium red | CAS 11103-72-3 is rated 5.0 out of 5 by 1.
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Synonym: Ammoniated ruthenium oxychloride; Ruthenium (III) Chloride Oxide Ammoniated; RR
Application: A voltage-sensitive calcium channel inhibitor
CAS Number: 11103-72-3
Molecular Weight: 786.35
Molecular Formula: Cl6H42N14O2Ru3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ruthenium red blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. Additionally, Ruthenium red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Ruthenium red is an inhibitor of Calcium Channel Protein, SERCA and TRPV. Ruthenium red is an inhibitor of CaM and Troponin C.


References

1. Bernardi, P., et al. 1984. Biochemistry. 23: 1645-1651. PMID: 6202317
2. Chahl, L.A. 1989. Eur. J. Pharmacol. 169: 241-247. PMID: 2478375
3. Charuk, J.H., et al. 1990. Anal. Biochem. 188: 123-131. PMID: 1699445
4. Masuoka, H., et al. 1990. Biochem. Biophys. Res. Commun. 169: 315-322. PMID: 1693502
5. Zacharová, D., et al. 1990. Gen. Physiol. Biophys. 9: 545-568. PMID: 1706675

Physical State :
Solid
Solubility :
Soluble in NH4OH, and water (10 mg/ml).
Storage :
Store at room temperature
Melting Point :
>500° C (dec.)
Density :
3.11 g/cm3
IC50 :
K+ -stimulated catecholamine secretion: IC50 = 6 µM; Transmembrane Ca2+ fluxe: IC50 = 7 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VM2656500
Merck Index :
14: 8300
MDL Number :
MFCD00011479
SMILES :
O([Ru++]O[Ru++])[Ru++].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].N([H])([H])[H].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]

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Certificate of Analysis

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Ruthenium red  Product Citations

See how others have used Ruthenium red. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 26217182  Adragna, NC. et al. 2015. Frontiers in cellular neuroscience. 9: 255.

PMID: # 25344384  Raffai, G. et al. 2015. J. Pharmacol. Exp. Ther. 352: 14-22.

PMID: # 24904214  Raffai, G. et al. 2014. Int J Nanomedicine. 9: 2557-66.

PMID: # 9204943  Acs, G. et al. 1997. J. Neurosci. 17: 5622-5628.

PMID: # 1715010  Amann, R. et al. 1991. Life Sci. 49: 849-856.

PMID: # 1705229  Amann, R. et al. 1990. Eur. J. Pharmacol. 186: 169-175.

PMID: # 2438415  Gutierrez-Gonzalvez, MG. et al. 1987. J Microsc. 145: 333-340.

PMID: # 93592  Dierichs, R. et al. 1979. Histochemistry. 64: 171-187.

Citations 1 to 8 of 8 total

Hi, I bought Ruthenium red (CAS 11103-72-3) and dilute in PBS without Ca2+. Is PBS without Ca2+ a good medium for dilution? That is the storage condition after the dilution? In -20C, 4C, -80C? Thank you.

Asked by: Seandddd
Thank you for your question. We do not have any solubility information for this chemical in PBS. This is soluble in water (10mg/ml) or ammonia. We recommend using solutions the same day they are used. If necessary to store, we suggest aliquoting and storing at -20ºC. If you have any further questions, please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-06-16
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Rated 5 out of 5 by from Yang Yang, LY. Et al. (PubMed 26348144) inhibited mitochondrial permeability transition induced by fullerenol via Ruthenium Red, a voltage-sensitive calcium channel inhibitor. -SCBT Publication Review
Date published: 2015-07-09
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