Rugulosin is an intense yellow pigment produced by some fungal species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. Rugulosin shows antibacterial and insecticidal activity and has found application as a bioinsecticide, notably as the active secondary metabolite in endophytic fungi of seedlings. Rugulosin (+ form) is an inhibitor of RNA Polymerase and RNase.
1. Breen, J., et al. 1955. Biochem. J. 60: 618-626. PMID: 13249956 2. Miller, J.D., et al. 2008. J. Chem. Ecol. 34: 362-368. PMID: 18266038 3. Watts P., et al. 2003. Mycol. Res. 107: 581-586. PMID: 12884955
Soluble in water (limited), ethanol, methanol, DMSO, and DMF.
Store at -20° C
980.03° C at 760 mmHg (Predicted)
1.88 g/cm3 (Predicted)
n20D 1.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Ueno et alUeno et al. (PubMed ID 7218376 ) found that when subcutaneously injected into rats, Rugulosin caused an elevation of serum transaminase activity and liver cell necrosis, revealing Rugulosin s nature as a slow-acting hepatotoxin. -SCBT Publication Review
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