(RS)-3,5-DHPGA selective metabotropic glutamate receptor agonist

(RS)-3,5-DHPG (CAS 19641-83-9)

(RS)-3,5-DHPG | CAS 19641-83-9 is rated 5.0 out of 5 by 1.
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Synonym: (RS)-3,5-Dihydroxyphenylglycine
Application: A selective metabotropic glutamate receptor agonist
CAS Number: 19641-83-9
Purity: ≥98%
Molecular Weight: 183.16
Molecular Formula: C8H9NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR-1 and mGluR-5.(RS)-3,5-DHPG is reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.


References

Ito et al (1992) 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors. NeuroReport 3 1013. Pellegrini-Giampietro et al (1996) Pharmacological characterization of metabotropic glutamate recpetors coupled to phopholipase D in the rat hippocampus. Br.J.Pharmacol. 118 1035. Mistry et al (1998) Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II-selective metabotropic glutamate receptor agonists. Br.J.Pharmacol. 123 581. Palmer et al (1998) The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36 1517.

Physical State :
Solid
Solubility :
Soluble in water (10 mM).
Storage :
Desiccate at -20° C
Boiling Point :
~448.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
pK Values :
pKa: 1.77 (Predicted), pKb: 10.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
108001
MDL Number :
MFCD00272595
SMILES :
C1=C(C=C(C=C1O)O)C(C(=O)O)N

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Certificate of Analysis

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Rated 5 out of 5 by from Kim Kim, HH. et al. (PubMed 25904792) reported that group I mGluR-specific agonist (RS)-3,5-Dihydroxyphenylglycine alone is not sufficient to activate phospholipase C in rat hippocampus, while glutamate robustly activates PLC. -SCBT Publication Review
Date published: 2015-05-13
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