RS-127445A 5-HT2B receptor antagonist with modest activity against other 5-HT receptors

RS-127445 (CAS 199864-87-4)

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Synonym: 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine
Application: A 5-HT2B receptor antagonist with modest activity against other 5-HT receptors
CAS Number: 199864-87-4
Molecular Weight: 281.3
Molecular Formula: C17H16FN3
* Refer to Certificate of Analysis for lot specific data (including water content).
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RS-127445 is a high affinity 5-HT2B receptor antagonist with a pIC50 of 10.4. The pKi of RS-127445 for the 5-HT2B receptor is 9.5. RS-127445 has 1000 fold selectivity over the human recombinant 5-HT2A, 5-HT2C, 5-HT5, 5-HT6 and 5-HT7 receptors.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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