RS-127445 is a high affinity 5-HT2B receptor antagonist with a pIC50 of 10.4. The pKi of RS-127445 for the 5-HT2B receptor is 9.5. RS-127445 has 1000 fold selectivity over the human recombinant 5-HT2A, 5-HT2C, 5-HT5, 5-HT6 and 5-HT7 receptors.
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