RR-SRC, Protein Tyrosine Kinase SubstrateA tyrosine kinase substrate used to measure the activity of tyrosine kinases

RR-SRC, Protein Tyrosine Kinase Substrate (CAS 81156-93-6)

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Synonym: Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly
Application: A tyrosine kinase substrate used to measure the activity of tyrosine kinases
CAS Number: 81156-93-6
Molecular Weight: 1519.66
Molecular Formula: C64H106N22O21
* Refer to Certificate of Analysis for lot specific data (including water content).
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RR-SRC is a tyrosine kinase substrate. RR-SRC has commonly been used to ascertain the activity of tyrosine kinases by measuring the phosphorylation of RR-SRC in both plant and animal cells. The substrate has also been used to monitor the purification of the insulin receptor, a protein tyrosine kinase. Tyrosine phosphorylation of RR-SRC is stimulated in vitro by EGF (epidermal growth factor).


References

1. Casnellie, J.E., et al. 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 282-286. PMID: 6804939
2. Pike, L.J., et al. 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 1443-1447. PMID: 6175968
3. Pike, L.J., et al. 1986. J. Biol. Chem. 261: 3782-3789. PMID: 3005300
4. Ashizawa, K., et al. 1998. Mol. Reprod. Dev. 49: 196-202. PMID: 9444662
5. Islas-Flores, I.I., et al. 1998. Plant Physiol. 118: 257-263. PMID: 9733545

Physical State :
Solid
Sequence :
N-Arg-Arg-Leu-Ile-Glu-Asp-Ala- Glu-Tyr-Ala-Ala-Arg-Gly-OH
Solubility :
Soluble in water (1 mg/ml - clear, colorless solution), 0.05 M acetic acid (10 mg/ml - clear, colorless solution), and 20% acetonitrile (1 mg/ml).
Storage :
Store at -20° C
Density :
1.50 g/cm3
Refractive Index :
n20D 1.65
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
25082794
MDL Number :
MFCD00076721
SMILES :
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N

Download SDS (MSDS)

Certificate of Analysis

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