Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium SaltA PKA inhibitor

Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (CAS 73208-40-9)

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Synonym: RP-CAMPS
Application: A PKA inhibitor
CAS Number: 73208-40-9
Molecular Weight: 367.3
Molecular Formula: C10H11N5O5PS•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (Rp-cAMP), a membrane permeable compound, is shown to be an an inhibitor of PKA (cAMP-dependent). This compound displays a capacity to inhibit dbcAMP- and Sp-cAMPS (sc -201571)-induced stimulation of bone resorption in mice. Furthermore, due to its effects on cAMP, Rp-cAMP can also inhibit cAMP mediated cell growth of certain cells. Other effects of PKA activation inhibition noted include a decrease in glucagon-induced glycogenolysis in hepatocytes isolated from fed rats.


References

1. Rothermel, J.D., et al. 1984. J. Biol. Chem. 259: 8151-8155. PMID: 6330102
2. Wang, L.Y., et al. 1991. Science. 253: 1132-1135. PMID: 1653455
3. Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182: 1356-1361. PMID: 1311571
4. Yokozaki, H., et al. 1992. Cancer Res. 52: 2504-2508. PMID: 1314695

Physical State :
Solid
Solubility :
Soluble in water, DMSO, methanol, and aqueous buffers.
Storage :
Store at -20° C
Ki Data :
PKA: Ki= 11 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCN(CC)CC.O[C@@H]1[C@@H]2OP(=S)(O)OC[C@H]2O[C@H]1n1cnc2c(N)ncnc12

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Certificate of Analysis

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Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium Salt  Product Citations

See how others have used Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22871966  Adriana R. Rodrigues et al. 2012. Mol. Endoc. 361: 69-79.

Citations 1 to 1 of 1 total
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