Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium SaltA PKA inhibitor

Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (CAS 73208-40-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 58ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: RP-CAMPS
Application: A PKA inhibitor
CAS Number: 73208-40-9
Molecular Weight: 367.3
Molecular Formula: C10H11N5O5PS•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (Rp-cAMP), a membrane permeable compound, is shown to be an an inhibitor of PKA (cAMP-dependent). This compound displays a capacity to inhibit dbcAMP- and Sp-cAMPS (sc -201571)-induced stimulation of bone resorption in mice. Furthermore, due to its effects on cAMP, Rp-cAMP can also inhibit cAMP mediated cell growth of certain cells. Other effects of PKA activation inhibition noted include a decrease in glucagon-induced glycogenolysis in hepatocytes isolated from fed rats.


1. Rothermel, J.D., et al. 1984. J. Biol. Chem. 259: 8151-8155. PMID: 6330102
2. Wang, L.Y., et al. 1991. Science. 253: 1132-1135. PMID: 1653455
3. Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182: 1356-1361. PMID: 1311571
4. Yokozaki, H., et al. 1992. Cancer Res. 52: 2504-2508. PMID: 1314695

Physical State :
Solubility :
Soluble in water, DMSO, methanol, and aqueous buffers.
Storage :
Store at -20° C
Ki Data :
PKA: Ki= 11 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium Salt  Product Citations

See how others have used Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22871966  Adriana R. Rodrigues et al. 2012. Mol. Endoc. 361: 69-79.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 53ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.