Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (Rp-cAMP), a membrane permeable compound, is shown to be an an inhibitor of PKA (cAMP-dependent). This compound displays a capacity to inhibit dbcAMP- and Sp-cAMPS (sc -201571)-induced stimulation of bone resorption in mice. Furthermore, due to its effects on cAMP, Rp-cAMP can also inhibit cAMP mediated cell growth of certain cells. Other effects of PKA activation inhibition noted include a decrease in glucagon-induced glycogenolysis in hepatocytes isolated from fed rats.
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See how others have used Rp-Adenosine 3prime,5prime-cyclic Monophosphorothioate, Sodium Salt. Click on the entry to view the PubMed entry .
PMID: # 22871966 Adriana R. Rodrigues et al. 2012. Mol. Endoc. 361: 69-79.
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