Rp-8-Br-PET-cGMPsCAS: 185246-32-6
MF: C18H14N5O6PSBr•Na
MW: 562.27
An inhibitor of cGKI and cGKII.

Rp-8-Br-PET-cGMPs (CAS 185246-32-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 136ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: p-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt; Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt
Application: An inhibitor of cGKI and cGKII
CAS Number: 185246-32-6
Purity: ≥98%
Molecular Weight: 562.27
Molecular Formula: C18H14N5O6PSBr•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGKI (Ki = 30 nM) and cGKII (cGMP-dependent protein kinase G) and blocks cGMP-gated retinal type ion channels (IC50 = 25 μmol).


References

Ibarra-Alvarado, C., et al, Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling. Mol. Pharmacol. 61, 312-319, (2002); Wei, J.Y., et al. , Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35, 16815-16823, (1996)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (15 mg/ml at ≥ 60° C).
Storage :
Desiccate at -20° C
Melting Point :
240-300° C(lit.)
IC50 :
cGMP-gated retinal type ion channels: IC50 = 25 µM
Ki Data :
PKG I: Ki= 30 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23695925
SMILES :
C1[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C4=C(C(=O)N5C=C(NC5=N4)C6=CC=CC=C6)N=C3Br)O)OP(=S)(O1)[O-].O.[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Rp-8-Br-PET-cGMPs  Product Citations

See how others have used Rp-8-Br-PET-cGMPs. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27092079  2016. Front Pharmacol. 7: 86.

Citations 1 to 1 of 1 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Rp-8-Br-PET-cGMPs, sc-215820, should be soluble in water at 15mg/ml at a temperature of approximately 60 ºC or less.
Answered by: TechService7
Date published: 2017-01-12
  • y_2020, m_1, d_23, h_12CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_215820, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 134ms
  • QUESTIONS, PRODUCT
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.