RP 67580CAS: 135911-02-3
MF: C29H30N2O2
MW: 438.57
A selective antagonist of the tachykinin NK1 receptor.

RP 67580 (CAS 135911-02-3)

RP 67580 | CAS 135911-02-3 is rated 5.0 out of 5 by 2.
  • y_2020, m_1, d_16, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_204894, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 131ms
  • REVIEWS, PRODUCT
5
2
4
0
3
0
2
0
1
0
Synonym: (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol
Application: A selective antagonist of the tachykinin NK1 receptor
CAS Number: 135911-02-3
Purity: ≥97%
Molecular Weight: 438.57
Molecular Formula: C29H30N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

RP 67580 is a potent and selective tachykinin NK-1R (NK1 receptor) antagonist. Displays higher affinity at rat and mouse than human receptors.


References

Garret et al (1991) Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc.Natl.Acad.Sci.USA 88 10208. Fong et al (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J.Biol.Chem. 267 25668. Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. Rupniak et al (1993) Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. Br.J.Pharmacol. 110 1607.

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (50 mM).
Storage :
Desiccate at -20° C
Melting Point :
246.84° C (Predicted)
Boiling Point :
~588.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Neurokinin 1 receptor: IC50 = 6.7 nM (rat); Neurokinin 1 receptor: IC50 = 8.7 nM (mouse); NK-1R: IC50 = 30 nM (human); Neurokinin 1 receptor: IC50 = 32 nM (guinea pig)
Ki Data :
NK1 receptor: Ki= 2.9 nM (rat); NK-1R: Ki= 25.12 nM (human); NK2 receptor: Ki= > 10 µM (rat); NK3 receptor: Ki= > 10 µM (rat)
pK Values :
pKb: 11.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NR3891000
PubChem CID :
107686
MDL Number :
MFCD00903364
SMILES :
COC1=CC=CC=C1CC(=N)N2C[[email protected]]3[[email protected]@H](C2)C(CCC3=O)(C4=CC=CC=C4)C5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

RP 67580  Product Citations

See how others have used RP 67580. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25501647  2015. Archives of dermatological research. 307: 171-81.

PMID: # 24704373  Sakamoto, K. et al. 2014. Eur. J. Pharmacol. 733: 13-22.

PMID: # 23637859  2013. PloS one. 8: e61574.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 131ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Société très efficiente Produits d'excellentes qualités, je suis uniquement responsable des achats mais je n'ai jamais de retours négatifs sur vos produits.
Date published: 2019-05-27
Rated 5 out of 5 by from Gao et al Gao et al. (PubMed ID 26079883) found that that pretreatment with RP 67580 attenuated ischemic injury by increasing SP expression. -SCBT Publication Review
Date published: 2015-03-07
  • y_2020, m_1, d_16, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_204894, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 25ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.