Rosmarinic AcidAn activator of GPR35

Rosmarinic Acid (CAS 20283-92-5)

Rosmarinic Acid | CAS 20283-92-5 is rated 5.0 out of 5 by 1.
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Synonym: (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid
Application: An activator of GPR35
CAS Number: 20283-92-5
Molecular Weight: 360.31
Molecular Formula: C18H16O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells. Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be an activator of GPR35.


References

1. Englberger, W., et al. 1988. Int. J. Immunopharmacol. 10: 729-737. PMID: 3198307
2. Makino, T., et al. 2000. Nephrol. Dial. Transplant. 15: 1140-1145. PMID: 10910436
3. Lee, J., et al. 2007. Biochem. Pharmacol. 74: 960-968. PMID: 17651699
4. Xu, Y., et al. 2010. J. Cell. Biochem. 111: 370-379. PMID: 20506543

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~15 mg/ml).
Storage :
Store at -20° C
Melting Point :
171-175° C
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
Antihemorrhagic activity: IC50 = 150 nM (mouse); HIV1 His6-tagged integrase: IC50 = 550 nM; Fyn: IC50 = 1.3 µM (human); Antioxidant activity against Cu2+-induced lipid peroxidation: IC50 = 1.81 µM; Mcl-1: IC50 = 2.03 µM (human)
Ki Data :
Fyn: Ki= 7.5 µM (human)
pK Values :
pKa: 2.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GD8990000
PubChem CID :
5281792
Merck Index :
14: 10300
MDL Number :
MFCD00017740
Beilstein Registry :
2227587
SMILES :
C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rosmarinic Acid  Product Citations

See how others have used Rosmarinic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26759705  Fernando, PM. et al. 2016. Biomol Ther (Seoul). 24: 75-84.

PMID: # 16604092  Lee, J. et al. 2006. British journal of pharmacology. 148: 366-75.

Citations 1 to 2 of 2 total

hi. i would like to know the purity precentage of the compound. (96%, 98% ?)

Asked by: erelhatan
Thank you for your question. The purity of this compound may vary from lot to lot. The purity of the most recent lot is >98.0 %. Please contact our technical service for information on the purity that would currently be available.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-21
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Rated 5 out of 5 by from Makino et al Makino et al. (PubMed ID 10910436) found that rosmarinic acid inhibited cytokine-induced cell proliferation and suppresses PDGF and c-myc mRNA expression in PDGF-stimulated mesangial cells. -SCBT Publication Review
Date published: 2015-03-29
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