Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells. Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be an activator of GPR35.
1. Englberger, W., et al. 1988. Int. J. Immunopharmacol. 10: 729-737. PMID: 3198307 2. Makino, T., et al. 2000. Nephrol. Dial. Transplant. 15: 1140-1145. PMID: 10910436 3. Lee, J., et al. 2007. Biochem. Pharmacol. 74: 960-968. PMID: 17651699 4. Xu, Y., et al. 2010. J. Cell. Biochem. 111: 370-379. PMID: 20506543
Soluble in water (100 mM), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~15 mg/ml).
hi. i would like to know the purity precentage of the compound. (96%, 98% ?)
Asked by: erelhatan
Thank you for your question. The purity of this compound may vary from lot to lot. The purity of the most recent lot is >98.0 %. Please contact our technical service for information on the purity that would currently be available.
Rated 5 out of
Makino et alMakino et al. (PubMed ID 10910436) found that rosmarinic acid inhibited cytokine-induced cell proliferation and suppresses PDGF and c-myc mRNA expression in PDGF-stimulated mesangial cells. -SCBT Publication Review
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