Rose Bengal lactoneA useful dye

Rose Bengal lactone (CAS 4159-77-7)

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Application: A useful dye
CAS Number: 4159-77-7
Purity: 95%
Molecular Weight: 973.67
Molecular Formula: C20H4Cl4I4O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rose Bengal lactone is a polyhalogenated derivative of Fluorescein (sc-215040, sc-206026). Rose Bengal lactone is a dye compound described to produce cell membrane damage. Rose Bengal lactone and other Fluorescein derivatives are also described to modulate the function of ATP-sensitive K+ channels.


References

1. de Weille, J.R., et al. 1992. J. Biol. Chem. 267: 4557-4563. PMID: 1311312
2. Lazarova, G. and Tashiro, H. 1995. Microbios. 82: 187-196. PMID: 7630327

Appearance :
Powder
Physical State :
Solid
Storage :
Store at room temperature
Melting Point :
280° C (lit.)(dec.)
Boiling Point :
~741.8° C at 760 mmHg (Predicted)
Density :
~3.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.96 (Predicted)
IC50 :
Beta-lactamase AmpC: IC50 = 0.47 µM (Escherichia coli K-12); Vesicular acetylcholine transporter: IC50 = 9.7 µM (rat); Chymotrypsin: IC50 = 50 µM (human); beta-Galactosidase : IC50 = 80 µM (human)
Ki Data :
VGLUT: Ki= 19 nM
pK Values :
pKa: 7.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
69439
MDL Number :
MFCD00013321
EC Number :
223-993-4
SMILES :
C1=C2C(=C(C(=C1I)O)I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)O)I

Download SDS (MSDS)

Certificate of Analysis

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