RolipramA selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4)

Rolipram (CAS 61413-54-5)

Rolipram | CAS 61413-54-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_17, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_3563, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 40ms
  • REVIEWS, PRODUCT
Synonym: SB 95952; ZK 62711
Application: A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4)
CAS Number: 61413-54-5
Purity: ≥97%
Molecular Weight: 275.35
Molecular Formula: C16H21NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.


References

1. Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127: 105-115. PMID: 3019721
2. Reeves, M.L., et al. 1987. Biochem. J. 241: 535-541. PMID: 3036066
3. Moore, J.B., et al. 1991. Biochem. Pharmacol. 42: 679-683. PMID: 1650219
4. Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270: 250-259. PMID: 8035322
5. Zhu, W.H., et al. 1998. Life Sci. 63: 265-274. PMID: 9698035
6. Bivalacqua, T.J., et al. 1999. J. Urol. 162: 1848-1855. PMID: 10524946
7. Sasaki, T., et al. 2007. Stroke. 38: 1597-1605. PMID: 17379823
8. Kaneda, T., et al. 2010. J Smooth Muscle Res. 46: 17-29. PMID: 20383031

Usage :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in water (0.2 mg/mL ), DMSO (7.3 mg/ml ), ethanol (7 mg/ml warm), DMF (~10 mg/ml ), DMF:PBS (pH 7.2, 1:9) (~0.5 mg/ml ), and acetone (25 mg/ml).
Storage :
Store at 4° C
Melting Point :
184.12° C (Predicted)
Boiling Point :
~472.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
IC50 :
cAMP-specific phosphodiesterase (PDE4): IC50 = 1 µM; C5a-stimulated LTC4 synthesis: IC50 = 200 nM (eosinophils); lipopolysaccharide-induced TNF synthesis: IC50 = 360 nM (monocytes); Phosphodiesterase 4A: IC50 = 4 nM (mouse); Phosphodiesterase 4B: IC50 = 34 nM (human); Phosphodiesterase 4D: IC50 = 25 nM (human); Phosphodiesterase 4C: IC50 = 25 nM (human)
Ki Data :
Phosphodiesterase 4A: Ki= 0.0023 nM (Rattus norvegicus); Phosphodiesterase 4D: Ki= 1.6 nM (human); Phosphodiesterase 4B: Ki= 3.8 nM (human); Phosphodiesterase 4C: Ki= 0.0023 nM (Rattus norvegicus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY5749237
PubChem CID :
5092
Merck Index :
14: 8251
MDL Number :
MFCD00270906
EC Number :
262-771-1
SMILES :
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Rolipram  Product Citations

See how others have used Rolipram. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 26416856  Euba, B. et al. 2015. Antimicrob. Agents Chemother. 59: 7581-92.

PMID: # 18641359  Hervé, R et al. 2008. J. Immunology. 181: 2196-2202.

PMID: # 18372231  Levallet, G. et al. 2008. J. Endocrinol. 197: 45-54.

PMID: # 16968783  Sohara, E. et al. 2006. Proc. Natl. Acad. Sci. USA. 103(38): 14217-14222.

PMID: # 15930146  Cheng, J. et al. 2005. Am. J. Physiol., Cell Physiol. 289: C959-C970.

PMID: # 16192372  Patwardhan, AM. et al. 2005. J Neurosci. 25(39): 8825-8832.

PMID: # 16177794  Dodge-Kafka KL et al. 2005. Nature. 437(7058): 574-578.

PMID: # 16083514  Yao, PL. et al. 2005. Respir. Res. 6: -.

PMID: # 11934820  Nagakura, A. et al. 2002. Br. J. Pharmacol. 135: 1783-1793.

PMID: # 10860936  McCawley, LJ. et al. 2000. Mol. Pharmacol. 58: 145-151.

Citations 1 to 10 of 11 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 59ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Levallet Levallet, et. al. (PubMed ID 18372231) used rolipram in their studies to identify the cAMP-PDE4 activity in subcellular fractions of cultured Sertoli cells (isolated from rats). -SCBT Publication Review
Date published: 2015-07-20
  • y_2019, m_9, d_17, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_3563, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.