RocaglaolAn active derivative of rocaglamide with antifungal and apoptotic activity

Rocaglaol (CAS 147059-46-9)

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Synonym: Ferrugin
Application: An active derivative of rocaglamide with antifungal and apoptotic activity
CAS Number: 147059-46-9
Purity: ≥97%
Molecular Weight: 434.48
Molecular Formula: C26H26O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rocaglaol is an active derivative of rocaglamide and has antifungal activity. Research shows that activation of the NF-κB p50 in T cells is strongly inhibited by derivatives of rocaglamides. Apoptosis and cell cycle arrest can be induced in LNCaP cells in the presence of rocaglaol.


References

1. Engelmeier, D., et al. 2000. J. Agric. Food Chem. 48: 1400-1404. PMID: 10775404
2. Chaidir, W.H., et al. 2001. J. Nat. Prod. 64: 1216-1220. PMID: 11575959
3. Baumann, B., et al. 2002. J. Biol. Chem. 277: 44791-44800. PMID: 12237314
4. Proksch, P., et al. 2005. J. Immunol. 174: 7075-7084. PMID: 15905551
5. Mi, Q., et al. 2006. Anticancer Res. 26: 947-952. PMID: 16619491

Physical State :
Solid
Solubility :
Soluble in DMSO or 100% ethanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5089
SMILES :
COC1=CC=C(C=C1)C23C(CC(C2(C4=C(C=C(C=C4O3)OC)OC)O)O)C5=CC=CC=C5

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Rocaglaol  Product Citations

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Citations 1 to 1 of 1 total

PMID: # 12237314  Baumann, B. et al. 2002. J. Biol. Chem. 277(47): 44791-800.

Citations 1 to 1 of 1 total
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