Ro 67-4853An allosteric group I mGluR activator

Ro 67-4853 (CAS 302841-89-0)

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Synonym: (9H-xanthene-9-carbonyl)carbamic acid butyl ester
Application: An allosteric group I mGluR activator
CAS Number: 302841-89-0
Molecular Weight: 325.36
Molecular Formula: C19H19NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ro 67-4853 is a positive allosteric modulator of mGluR group I receptors (mGluR-1 and mGluR-5) (pEC50 value is 7.16 for the rat mGluR-1a receptor). Ro 67-4853 show activity at all group I receptors and enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
218.03° C (Predicted)
Boiling Point :
511.62° C (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
(S)-DHPG: EC5050 = 95 nM (CA3 neurons)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9949202
MDL Number :
MFCD20270618
SMILES :
CCCCOC(=O)NC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13

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Certificate of Analysis

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