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Ro 60-0175 fumarate (CAS 169675-09-6)

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Alternate Names:
(aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate
Application:
Ro 60-0175 fumarate is a potent and selective SR-2 agonist
CAS Number:
169675-09-6
Purity:
≥98%
Molecular Weight:
342.75
Molecular Formula:
C11H12ClFN2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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Ro 60-0175 fumarate is a research compound that is utilized in the field of neuroscience, particularly in studies related to neurotransmitter systems. Its main application lies in investigating the modulation of serotonergic signaling pathways. As a selective agonist, Ro 60-0175 fumarate is used to activate specific serotonin receptors in experimental applications, aiding in the elucidation of their roles in neuronal communication. The fumarate salt form of this compound provides enhanced solubility for in vitro experiments. In behavioral studies, Ro 60-0175 fumarate allows researchers to observe the effects of serotonergic activation, contributing to the broader understanding of serotonin′s impact on behavior and neural function. This compound also serves as a tool to explore potential targets for new research chemicals that might modulate serotonergic systems. It is important in the synthesis of analogs and derivatives for structure-activity relationship studies, paving the way for the discovery of novel compounds with specific receptor affinity profiles.


Ro 60-0175 fumarate (CAS 169675-09-6) References

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  4. Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons.  |  Theile, JW., et al. 2009. J Pharmacol Exp Ther. 329: 625-33. PMID: 19225162
  5. Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.  |  Pratt, WE., et al. 2009. Behav Neurosci. 123: 1046-57. PMID: 19824770
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  7. Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine.  |  Cathala, A., et al. 2015. Addict Biol. 20: 445-57. PMID: 24661380
  8. Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra.  |  Burke, MV., et al. 2014. J Neurochem. 131: 432-43. PMID: 25073477
  9. Serotonin2C receptor stimulation inhibits cocaine-induced Fos expression and DARPP-32 phosphorylation in the rat striatum independently of dopamine outflow.  |  Devroye, C., et al. 2015. Neuropharmacology. 89: 375-81. PMID: 25446572
  10. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.  |  Rüedi-Bettschen, D., et al. 2015. Psychopharmacology (Berl). 232: 2959-68. PMID: 25877746
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  12. Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.  |  Griffin, AL., et al. 2019. Brain Commun. 1: fcz008. PMID: 31667472
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ro 60-0175 fumarate, 10 mg

sc-204890
10 mg
$145.00
US: Only available in the US

Ro 60-0175 fumarate, 50 mg

sc-204890A
50 mg
$615.00
US: Only available in the US