RO-3306 CAS: 872573-93-8
MF: C18H13N3OS2
RO-3306 is an inhibitor of CDK1/cyclin B1 and CDK1/cyclin A.

RO-3306 (CAS 872573-93-8)

RO-3306 | CAS 872573-93-8 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Application: RO-3306 is an inhibitor of CDK1/cyclin B1 and CDK1/cyclin A
CAS Number: 872573-93-8
Purity: ≥95%
Molecular Weight: 351.44
Molecular Formula: C18H13N3OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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RO-3306 has been shown to inhibit CDK1/cyclin B1 and CDK1/cyclin A. RO-3306 reversibly arrests human cells at the G2/M border of the cell cycle. RO-3306 allows for effective cell synchronization in early mitosis.

Physical State :
Solid
Solubility :
DMSO (5mg/ml).
Storage :
Store at -20° C
Melting Point :
234.00° C (Predicted)
Boiling Point :
~569.1° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC2=C(C=CC(=C2)/C=C\\3/C(=O)N=C(S3)NCC4=CC=CS4)N=C1

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Certificate of Analysis

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RO-3306 (CAS 872573-93-8)  Product Citations

See how others have used RO-3306 (CAS 872573-93-8). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 30 total

PMID: # 33657372  Branigan, TB.|Kozono, D.|Schade, AE.|Deraska, P.|Rivas, HG.|Sambel, L.|Reavis, HD.|Shapiro, GI.|D'Andrea, AD.|DeCaprio, JA.| et al. 2021. Cell Rep. 34: 108808.

PMID: # 31321035  Kwiatkowski, BA.|Burwick, NR.|Richard, RE.| et al. 2019. Biomark Res. 7: 13.

PMID: # 31291580  Zhang, K.|Lv, DW.|Li, R.| et al. 2019. Cell Rep. 28: 449-459.e5.

PMID: # 30321399  Werwein, E. et al. 2018. Nucleic Acids Res.

PMID: # 29361176  Dilworth, D. et al. 2018. Nucleic Acids Res. 46: 2459-2478.

PMID: # 29254517  Wakida, T.|Ikura, M.|Kuriya, K.|Ito, S.|Shiroiwa, Y.|Habu, T.|Kawamoto, T.|Okumura, K.|Ikura, T.|Furuya, K.| et al. 2017. Elife. 6:

PMID: # 29021609  Bischof, J. et al. 2017. Nat Commun. 8: 849.

PMID: # 28360195  Giráldez, S. et al. 2017. FASEB J. 31: 2925-2936.

PMID: # 28904862  Momand, J.|Magdziarz, P.|Feng, Y.|Jiang, D.|Parga, E.|Celis, A.|Denny, E.|Wang, X.|Phillips, ML.|Monterroso, E.|Kane, SE.|Zhou, F.| et al. 2017. FEBS Open Bio. 7: 1328-1337.

PMID: # 29445399  Xing, X.|Mroß, C.|Hao, L.|Munck, M.|Herzog, A.|Mohr, C.|Unnikannan, CP.|Kelkar, P.|Noegel, AA.|Eichinger, L.|Neumann, S.| et al. 2017. Int J Cell Biol. 2017: 8607532.

Citations 1 to 10 of 30 total
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Rated 5 out of 5 by from Czaplinski et al Czaplinski et al. (PubMed ID 26046302) used RO-3306 to ininhibit CDK1 to decrease cell death by interfering with mitotic arrest and preventing the phosphorylation of BCl-2 and BCL-XL along with MCL-1 downregulation. -SCBT Publication Review
Date published: 2015-04-20
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