Ro 16-6491A selective reversible MAO-B inhibitor devoid of indirect sympathomimetic activity

Ro 16-6491 (CAS 94319-79-6)

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Application: A selective reversible MAO-B inhibitor devoid of indirect sympathomimetic activity
CAS Number: 94319-79-6
Molecular Weight: 235.1
Molecular Formula: C9H11ClN2O·HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ro 16-6491 is a selective, reversible MAO-B (monoamine oxidase- β) inhibitor which is devoid of indirect sympathomimetic activity.


References

1. Cesura, A.M., et al. 1988. J. Neurochem. 50: 1037-1043. PMID: 3126263
2. Cesura, A.M., et al. 1988. Pharmacol Res Commun. 20: 51-61. PMID: 3244727
3. Cesura, A.M., et al. 1990. Biochem. Pharmacol. 39: 216-220. PMID: 2297358

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
216-217° C
Boiling Point :
404.2° C at 760 mmHg (Predicted)
IC50 :
b-Phenylehtylamine: IC50 = 0.02 µM (rat brain homogenates); 5-HT : IC50 = 200 µM (rat brain homogenates)
pK Values :
pKa: 13.99 (Predicted), pKb: 8.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5702251
MDL Number :
MFCD00078595
SMILES :
Cl.NCCNC(=O)C1=CC=C(Cl)C=C1

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Certificate of Analysis

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