RO 15-4513 is a high affinity benzodiazepine ligand which acts as a partial inverse agonist at recombinant diazepam-sensitive (DS) benzodiazepine α1-, α2-, α3- and α5-GABAA receptors. It has also been shown to activate GABAA R α4 and GABAA R α6. In addition, RO 15-4513 acts as a partial agonist at diazepam-insensitive (DI) benzodiazepine receptors. Furthermore, studies show that ethanol can inhibit the binding of RO 15-4513 to α4/6β3δ GABAA receptors. RO 15-4513 has a similar structure to flumazenil, which differs by an azido group at the C7 position of the imidazo-benzodiazepine ring.
1. Turner, D.M., et al. 1991. J. Pharmacol. Exp. Ther. 257: 1236-1242. PMID: 1646328 2. Wong, G. and Skolnick, P. 1992. Eur. J. Pharmacol. 225: 63-68. PMID: 1311690 3. Hanchar, H.J., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 8546-8551. PMID: 16581914
Soluble in ethanol (5 mM), DMSO (10 mM), methanol, and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.8 mg/ml). Insoluble in water.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn