Molecular structure of RO 15-4513, CAS Number: 91917-65-6
RO 15-4513 (CAS 91917-65-6)
Alternate Names:
8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Application:
RO 15-4513 is a high affinty benzodiazepine ligand and GABAA antagonist
CAS Number:
91917-65-6
Molecular Weight:
326.31
Molecular Formula:
C15H14N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RO 15-4513 is a high affinity benzodiazepine ligand which acts as a partial inverse agonist at recombinant diazepam-sensitive (DS) benzodiazepine α1-, α2-, α3- and α5-GABAA receptors. In addition, RO 15-4513 acts as a partial agonist at diazepam-insensitive (DI) benzodiazepine receptors. Furthermore, studies show that ethanol can inhibit the binding of RO 15-4513 to α4/6β3δ GABAA receptors. Also RO 15-4513 has a similar structure to flumazenil, which differs by an azido group at the C7 position of the imidazo-benzodiazepine ring.
RO 15-4513 (CAS 91917-65-6) References
- High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. | Wong, G. and Skolnick, P. 1992. Eur J Pharmacol. 225: 63-8. PMID: 1311690
- Ro 15-4513 binding to GABAA receptors: subunit composition determines ligand efficacy. | Wong, G. and Skolnick, P. 1992. Pharmacol Biochem Behav. 42: 107-10. PMID: 1326771
- The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam. | Turner, DM., et al. 1991. J Pharmacol Exp Ther. 257: 1236-42. PMID: 1646328
- Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. | Hanchar, HJ., et al. 2006. Proc Natl Acad Sci U S A. 103: 8546-51. PMID: 16581914
- Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors. | Linden, AM., et al. 2011. Front Neurosci. 5: 3. PMID: 21270945
- Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat. | Corda, MG., et al. 1989. Eur J Pharmacol. 159: 233-9. PMID: 2537736
- RO 15-4513 and its interaction with ethanol. | Lister, RG. and Nutt, DJ. 1988. Adv Alcohol Subst Abuse. 7: 119-23. PMID: 2851930
- Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol. | Bonetti, EP., et al. 1988. Pharmacol Biochem Behav. 31: 733-49. PMID: 2855118
- Effects of Ro 15-4513, alone or in combination with ethanol, Ro 15-1788, diazepam, and pentobarbital on instrumental behaviors of rats. | Hiltunen, AJ. and Järbe, TU. 1988. Pharmacol Biochem Behav. 31: 597-603. PMID: 3150785
- Differential interactions between ethanol and Ro 15-4513 on two anxiety tests in rats. | Prunell, M., et al. 1994. Pharmacol Biochem Behav. 47: 147-51. PMID: 8115416
Activator of:
GABAA R α 4, and GABAA R α 6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RO 15-4513, 10 mg | sc-203683 | 10 mg | $407.00 | |||
| US: Only available in the US | ||||||