RO 106-9920 is a cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. RO 106-9920 acts as a highly selective, irreversible inhibitor of IκBaee ubiquitination. RO 106-9920 blocks NF-κB-dependent cytokine expression in human PBMNs and rats. RO 106-9920 does not inhibit SCFbTRCP (IκBa ubiquitin ligase)-mediated b-catenin ubiquitination in Jurkat cells. At 10 μM concentrations, this compound also inhibits the activities of 5-LO (5-lipoxygenase), EGFR kinase and NOS2 (iNOS).
1. Swinney, D.C., et al. 2002. J. Biol. Chem. 277: 23573-23581. PMID: 11950839
See how others have used RO 106-9920. Click on the entry to view the PubMed entry .
PMID: # 26670488 2016. Am. J. Physiol. Endocrinol. Metab. 310: E289-300.
PMID: # 25965265 Rajalakshmy, AR. et al. 2015. PLoS ONE. 10: e0125419.
PMID: # 23359428 2013. J. Cell. Physiol. 228: 1745-53.
PMID: # 22847000 Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.
PMID: # 23028567 2012. PLoS ONE. 7: e44622.
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