RO 106-9920A NF-kB-dependent cytokine expression, 5-LO, and EGFR inhibitor

RO 106-9920 (CAS 62645-28-7)

RO 106-9920 | CAS 62645-28-7 is rated 5.0 out of 5 by 1.
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Synonym: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Application: A NF-kB-dependent cytokine expression, 5-LO, and EGFR inhibitor
CAS Number: 62645-28-7
Purity: >95%
Molecular Weight: 245.3
Molecular Formula: C10H7N5OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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RO 106-9920 is a cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. RO 106-9920 acts as a highly selective, irreversible inhibitor of IκBaee ubiquitination. RO 106-9920 blocks NF-κB-dependent cytokine expression in human PBMNs and rats. RO 106-9920 does not inhibit SCFbTRCP (IκBa ubiquitin ligase)-mediated b-catenin ubiquitination in Jurkat cells. At 10 μM concentrations, this compound also inhibits the activities of 5-LO (5-lipoxygenase), EGFR kinase and NOS2 (iNOS).


References

1. Swinney, D.C., et al. 2002. J. Biol. Chem. 277: 23573-23581. PMID: 11950839

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mM), DMSO (12 mg/ml), and water (6.32 mg/ml) at 25° C.
Storage :
Store at -80° C
Melting Point :
175.69° C (Predicted)
Boiling Point :
420.98° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.86
IC50 :
IκBαee ubiquitination: IC50 = 2.3 µM; TNF-α, IL-1β, and IL-6: IC50 = ~700 nM (human PBMNs)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3906779
MDL Number :
MFCD06660085
SMILES :
C1=CC=C(C=C1)S(=O)C2=NN3C(=NN=N3)C=C2

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Certificate of Analysis

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RO 106-9920  Product Citations

See how others have used RO 106-9920. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 26670488  2016. Am. J. Physiol. Endocrinol. Metab. 310: E289-300.

PMID: # 25965265  Rajalakshmy, AR. et al. 2015. PLoS ONE. 10: e0125419.

PMID: # 23359428  2013. J. Cell. Physiol. 228: 1745-53.

PMID: # 23028567  2012. PLoS ONE. 7: e44622.

PMID: # 22847000  Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Swinney et al Swinney et al. (PubMed ID 11950839) found that RO 106-9920 prevented lipopolysaccharide-dependent expression of TNFalpha, interleukin-1beta, and interleukin-6 in fresh human peripheral blood mononuclear cells. -SCBT Publication Review
Date published: 2015-04-18
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