RN 1747CAS: 1024448-59-6
MF: C17H18CIN3O4S
MW: 395.87
A potent and selective TRPV4 agonist.

RN 1747 (CAS 1024448-59-6)

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Synonym: 1-(4-Chloro-2-nitrophenyl)sulfonyl- 4-benzylpiperazine; 4-chloro-2-nitro-1-((4-benzylpiperazinyl)sulfonyl)benzene; 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine
Application: A potent and selective TRPV4 agonist
CAS Number: 1024448-59-6
Purity: >97%
Molecular Weight: 395.87
Molecular Formula: C17H18CIN3O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Shown to display selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also has been shown to antagonize TRPM8 at relevant concentrations (IC50 = 4 μM).


References

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Melting Point :
131-133° C
Boiling Point :
534° C
Density :
~1.42 g/cm3 (Predicted)
Refractive Index :
n20D ~1.64 (Predicted)
IC50 :
hTRPV4: EC5050 = 0.77 µM; mTRPV4: EC5050 = 4.0 µM; rTRPV4: EC5050 = 4.1 µM; TRPM8 receptors: EC5050 = >30 µM; TRPV3 receptors: EC5050 = >30 µM; TRPV1 receptors: EC5050 = >100 µM; TRPM8: IC50 = 4 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
5068295
MDL Number :
MFCD04154169
SMILES :
C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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