RK-682, Streptomyces sp. is an effective tyrosine phosphatase inhibitor that does not permeate the cell membrane. The inhibitor has been reported to inhibit the G1/S transition of the cell cycle, the dephosporylation activity of VHR and CD45, and also enhanced levels of phosphotyrosine in Ball-1 cells. VHR dephosphorylates activated ERK1/2 and reduces the strengths of the ERK signaling cascade. Studies demonstrate that RK-682 can enhance ATP-induced long term potentiation in guinea-pig hippocampal CA1 neurons. RK-682, Streptomyces sp. is an inhibitor of CD45, PTP1B and VHR.
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