RK-682, Streptomyces sp.An effective tyrosine phosphatase inhibitor

RK-682, Streptomyces sp. (CAS 154639-24-4)

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Application: An effective tyrosine phosphatase inhibitor
CAS Number: 154639-24-4
Purity: ≥98%
Molecular Weight: 368.5
Molecular Formula: C21H36O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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RK-682, Streptomyces sp. is an effective tyrosine phosphatase inhibitor that does not permeate the cell membrane. The inhibitor has been reported to inhibit the G1/S transition of the cell cycle, the dephosporylation activity of VHR and CD45, and also enhanced levels of phosphotyrosine in Ball-1 cells. VHR dephosphorylates activated ERK1/2 and reduces the strengths of the ERK signaling cascade. Studies demonstrate that RK-682 can enhance ATP-induced long term potentiation in guinea-pig hippocampal CA1 neurons. RK-682, Streptomyces sp. is an inhibitor of CD45, PTP1B and VHR.


References

1. Hamaguchi, T., et al. 1995. FEBS Lett. 372: 54-58. PMID: 7556642
2. Fujii, S., et al. 1995. Neurosci. Lett. 187: 130-132. PMID: 7783959
3. Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540. PMID: 20608179

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), 100% ethanol (10 mg/ml), methanol, DMF, heptane (≥8 mg/ml), and xylene (≥8 mg/ml).
Storage :
Store at -20° C
Melting Point :
219.71° C (Predicted)
Boiling Point :
507.76° C at 760 mmHg (Predicted)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
dephosphorylation activity of CD45: IC50 = 54 µM; VHR: IC50 = 2 µM; Cdc25B: IC50 = ~42 µM; PTP1B: IC50 = ~42 µM
pK Values :
pKa: 4.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
54685915
MDL Number :
MFCD20488046
SMILES :
CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O

Download SDS (MSDS)

Certificate of Analysis

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