RK-682 is the calcium salt of 3-hexadecanoyl-5-hydroxymethyl-tetronic acid, a naturally-occurring specific inhibitor of protein tyrosine phosphatase (PTPase). specifically PTP1B. RK-682 is reported to inhibit dephosphorylation activity of CD45 (IC50 = 54 microM) and VHR (IC50 = 2.0 microM), and to arrest cell cycle progress at the G1/S transition. Studies with RK-682 and derivatives have demonstrated efficacy in inhibiting HIV-1 protease activity. RK-682 also displays activity against heparanase function, a protein indicated as operative in tumor cell invasion and angiogenesis.
1. Roggo, B.E., et al. 1994. J. Antibiot. 47: 136-142. PMID: 8150707
2. Hamaguchi, T., et al. 1995. FEBS Lett. 372: 54-58. PMID: 7556642
3. Ishida, K., et al. 2004. Mol. Cancer Ther. 3: 1069-1077. PMID: 15367701
See how others have used RK-682. Click on the entry to view the PubMed entry .
PMID: # 16545563 Na, M. et al. 2006. Bioorg. Med. Chem. Lett. 16: 3061-3064.
PMID: # 15367701 Ishida, K. et al. 2004. Mol. Cancer Ther. 3: 1069-1077.
PMID: # 7556642 Hamaguchi, T. et al. 1995. FEBS Lett. 372: 54-58.
PMID: # 7783960 Fujii, S. et al. 1995. Neurosci. Lett. 187: 133-136.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.