RitodrineA β2-adrenoceptor agonist that acts as an adrenergic receptor stimulant

Ritodrine (CAS 23239-51-2)

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Synonym: Ritodrina; Ritodrinium
Application: A β2-adrenoceptor agonist that acts as an adrenergic receptor stimulant
CAS Number: 23239-51-2
Purity: ≥98%
Molecular Weight: 323.81
Molecular Formula: C17H21NO3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ritodrine is a β2-AR (β2-adrenoceptor) agonist that acts as an adrenergic receptor stimulant. gives priority to act on the adrenergic receptors on the uterine smooth muscle through membrane-mediated effects of uterine smooth muscle cells, and uterine smooth muscle cells β2-AR (β2-adrenoceptor). Which activates cell membrane adenylate cyclase to adenosine triphosphate into cyclic adenosine monophosphate (cAMP), leading to increased intracellular cAMP, thus reducing myosin light chain kinase activity in reducing intracellular calcium concentration at the same time.


References

Bassett JM, Symonds ME Am. J. Physiol. 275:R112-R119 (1998).

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO, and methanol.
Storage :
Store at room temperature
Melting Point :
195-197° C
Boiling Point :
512.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Beta-2 adrenergic receptor: IC50 = 23.99 nM (rat); Beta-3 adrenergic receptor: EC5050 = 190.55 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DO6524000
PubChem CID :
31728
Merck Index :
14: 8237
MDL Number :
MFCD01657514
EC Number :
245-514-8
SMILES :
C[C@@H]([C@@H](C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O.Cl

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Certificate of Analysis

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Ritodrine  Product Citations

See how others have used Ritodrine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25941087  2015. Eur. J. Pharmacol. 761: 125-9.

Citations 1 to 1 of 1 total
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