RifabutinA semisynthetic antibacterial derivative of Rifamycin S

Rifabutin (CAS 72559-06-9)

Rifabutin | CAS 72559-06-9 is rated 5.0 out of 5 by 1.
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Synonym: Ansatipine; Ansamycin; Mycobutin
Application: A semisynthetic antibacterial derivative of Rifamycin S
CAS Number: 72559-06-9
Molecular Weight: 847.00
Molecular Formula: C46H62N4O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rifabutin is a semisynthetic derivative of Rifamycin S. It acts as an antibacterial (tuberculostatic) that inhibits nucleic acid synthesis.


References

O'Brien, R.J., et al.: Infect. Dis., 9, 519 (1987), Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),

Physical State :
Solid
Solubility :
Soluble in water (partly), methanol, chloroform, DMSO (60 mg/ml at 25° C), and ethanol (40 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
148-151° C
Boiling Point :
~969.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Vero: IC50 > 46.6 µM (Chlorocebus aethiops)
pK Values :
pKa: 3.31 (Predicted), pKb: 9.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VJ6700000
PubChem CID :
6323490
Merck Index :
14: 8213
MDL Number :
MFCD00866816
Beilstein Registry :
3584778
SMILES :
C[C@H]1/C=C/C=C(\\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)/C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Verma et al Verma et al. (PubMed ID 23562366) found that inhalable microparticles of nitric oxide donors, like rifabutin, induce phagosome maturation and kill Mycobacterium tuberculosis. -SCBT Publication Review
Date published: 2015-02-27
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