RHOD 2/AMA membrane permeable fluoregenic probe for intracellular Ca2+

RHOD 2/AM (CAS 129787-64-0)

RHOD 2/AM | CAS 129787-64-0 is rated 5.0 out of 5 by 1.
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Application: A membrane permeable fluoregenic probe for intracellular Ca2+
CAS Number: 129787-64-0
Purity: >90%
Molecular Weight: 1123.96
Molecular Formula: C52H59N4O19•Br
* Refer to Certificate of Analysis for lot specific data (including water content).
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RHOD 2/AM is a membrane permeable form of RHOD 2 which operates in the visible spectrum. Used as a fluorescent probe for intracellular Ca2+. RHOD 2/AM binds to Ca2+ once it is hydrolyzed to RHOD 2 by endogenous esterases inside cells.


References

1. Minta, A., et al. 1989. J. Biol. Chem. 264: 8171-8178. PMID: 2498308
2. Quinton, T.M., et al. 1992. Biochem. Biophys. Res. Commun. 184: 893-899. PMID: 1315537
3. Okada, M., et al. 1992. Brain Res. 583: 227-236. PMID: 1387038
4. Tamura, Y., et al. 1992. Brain Res. 592: 317-325. PMID: 1360313
5. Melamed, N., et al. 1993. J. Neurosci. 13: 632-649. PMID: 8426230

Physical State :
Solid
Solubility :
Soluble in DMSO, DMF, methanol, and chloroform.
Storage :
Store at -20° C
Fluoresence :
λex 550 nm, λem 578 nm in methanol; λex 546 nm in CHCl3/CH3OH; λex 552 nm in Buffer pH 7 ; λex 549 nm, λem 578 nm in DMSO; λex 550 nm, λem 570 nm in Chloroform:Methanol (90:10)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
25229581
MDL Number :
MFCD00082575
SMILES :
CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=CC(=C3C4=C(C=C(C=C4)N(C)C)OC5=C3C=CC(=C5)N(C)C)C=CC2=[N+](CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C.[Br-]

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Certificate of Analysis

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RHOD 2/AM  Product Citations

See how others have used RHOD 2/AM. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30258205  Walsh, TG.|van den Bosch, MTJ.|Lewis, KE.|Williams, CM.|Poole, AW.| et al. 2018. Sci Rep. 8: 14377.

PMID: # 24586099  Chang, G. et al. 2014. Exp. Biol. Med. (Maywood). 239: 414-22.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Duan ZZ; et al Duan ZZ; et al. (PubMed ID:26320687) utilized RHOD 2/AM to detect mitochondrial membrane potential and mitochondrial permeability transition pore (mPTP) opening. -SCBT Publication Review
Date published: 2015-02-14
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