Rho Kinase Inhibitor is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of ROCK (G-protein Rho-associated kinase). The compound exhibits a much weaker affinity for other serine/threonine kinases. Rho Kinase Inhibitor has been shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS in NT-2 cells.
Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
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