Rhapontigenin CAS: 500-65-2
MF: C15H14O4
MW: 258.27

Rhapontigenin (CAS 500-65-2)

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Alternate Names: Rhapontigenin is known as a natural analog of resveratrol.
Application: ARhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1, with antioxidant and anti-cancer activity.
CAS Number: 500-65-2
Purity: ≥98%
Molecular Weight: 258.27
Molecular Formula: C15H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, Rhapontigenin inhibits the proliferation of Hep-G2 and HL-60R cancer cell lines (IC50 = 48 μM).


References

1 Chun, Y.J., Ryu, S.Y., Jeong, T.C., et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos 29(4) 389-393 (2001).
2 Roupe, K.A., Helms, G.L., Halls, S.C., et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: Applications to metabolism, pharmacokinetics and anti-cancer studies. J Pharm Pharmaceut Sci 8(3) 374-386 (2005).
3 Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 3546-3554 (2003).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
COC1=C(C=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O)O

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Rhapontigenin (CAS 500-65-2)  Product Citations

See how others have used Rhapontigenin (CAS 500-65-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28248427  Paasela, T. et al. 2017. New Phytol. 214: 1537-1550.

PMID: # 32366266  Cell Commun. Signal. 18: 70.

Citations 1 to 2 of 2 total
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