RetrorsineA cytotoxic pyrrolizidine alkaloid compound

Retrorsine (CAS 480-54-6)

Retrorsine | CAS 480-54-6 is rated 5.0 out of 5 by 1.
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Synonym: β-Longilobine
Application: A cytotoxic pyrrolizidine alkaloid compound
CAS Number: 480-54-6
Purity: ≥90%
Molecular Weight: 351.39
Molecular Formula: C18H25NO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Retrorsine, a pyrrolizidine alkaloid, is a mutagenic, antimitotic, and cytotoxic compound. The toxicity of retrorsine relies on its bioactivation by cytochrome P450 enzymes (CYP). The toxicity of retrorsine has been shown to result from one of two compounds that are generated after CYP metabolism of retrorsine.


References

1. Gordon, G.J., et al. 2000. Exp. Mol. Pathol. 69: 17-26. PMID: 10891289

2. Wang, Y.P., et al. 2005. Int J Environ Res Public Health. 2: 74-79. PMID: 16705803

3. Dai, J., et al. 2010. Chem. Biol. Interact. 183: 49-56. PMID: 19818743

Usage :
Retrorsine is slightly soluble in both Chloroform and Methanol.
Physical State :
Solid
Solubility :
Soluble in Chloroform (25 mg/ mL) and ethanol
Storage :
Store at -20° C
Melting Point :
208-211° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5281743
SMILES :
C/C=C\\1/C[C@H]([C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(CO)O)C

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Certificate of Analysis

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Rated 5 out of 5 by from Dai et al Dai et al. (PubMed ID 19818743) found that retrorsine inactivated 3A4 in the presence of NADPH. -SCBT Publication Review
Date published: 2015-01-09
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