Resolvin D2A lipid mediator

Resolvin D2 (CAS 810668-37-2)

Resolvin D2 | CAS 810668-37-2 is rated 5.0 out of 5 by 1.
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Application: A lipid mediator
CAS Number: 810668-37-2
Purity: ≥95%
Molecular Weight: 376.5
Molecular Formula: C22H32O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.


References

1 Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003). 2 Ariel, A., Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007). 3 Spite, M., Norling, L.V., Summers, L., et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268) 1287-1291 (2009).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in PBS pH 7.2 (~0.05 mg/ml), DMSO (~50 mg/ml), and DMF (~50 mg/ml).
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1170, Class 3, Packing group II
PubChem CID :
11383310
MDL Number :
MFCD18427928
SMILES :
CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CCC(=O)O)O)O)O

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Resolvin D2  Product Citations

See how others have used Resolvin D2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28086928  Pascoal, LB. et al. 2017. J Neuroinflammation. 14: 5.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Tian et al Tian et al. (PubMed ID 25824039) found that resolvin D2 is a microglia inflammatory inhibitor that blocks TLR4/NF- B pathway activation. -SCBT Publication Review
Date published: 2015-04-18
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