RebeccamycinAn indolocarbazole topoisomerase inhibitor

Rebeccamycin (CAS 93908-02-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 157ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An indolocarbazole topoisomerase inhibitor
CAS Number: 93908-02-2
Purity: ≥98%
Molecular Weight: 570.4
Molecular Formula: C27H21Cl2N3O7
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Rebeccamycin is an indolocarbazole small molecule antibiotic, functional as an inhibitor of Topo I (DNA topoisomerase I). It is suggested that Rebeccamycin and the other related indolocarbazoles intercalate into DNA and prevent topoisomerase activity from a position on the backbone. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. The glycosyl moiety is also shown to be essential for the translocation of Rebeccamycin from the lipid membrane into the vital structures of the cell.


1. Bush, J.A., et al. 1987. J. Antibiot. 40: 668-678. PMID: 3112080
2. Bailly, C., et al. 1997. Biochemistry. 36: 3917-3929. PMID: 9092822
3. Anizon, F., et al. 1997. J. Med. Chem. 40: 3456-3465. PMID: 9341921
4. Anizon, F., et al. 1998. Bioorg. Med. Chem. 6: 1597-1604. PMID: 9801830
5. Bailly, C., et al. 1999. Chem. Biol. 6: 277-286. PMID: 10322124
6. Goossens, J.F., et al. 2000. Eur. J. Pharmacol. 389: 141-146. PMID: 10688977
7. Long, B.H., et al. 2002. Curr Med Chem Anticancer Agents. 2: 255-266. PMID: 12678746
8. Woo, M.H., et al. 2002. J. Biol. Chem. 277: 3813-3822. PMID: 11733535

Physical State :
Derived From :
Lechevalieria sp.
Solubility :
Soluble in DMSO (≥3 mg/ml), THF, and methanol (≤0.2 mg/ml).
Storage :
Store at -20° C
Density :
1.88 g/cm3 (Predicted)
Refractive Index :
n20D 1.84 (Predicted)
IC50 :
L1210: IC50 = 100 nM (mouse); K562: IC50 = 200 nM (human); A549: IC50 = 300 nM (human); B16 melanoma cells: IC50 = 480 nM (mouse); P388 leukemia cells: IC50 = 500 nM
pK Values :
pKa: 9.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 50ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 41ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.