Rauwolscine • HCl (CAS 6211-32-1)
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Alternate Names:
α-Yohimbine hydrochloride
Application:
Rauwolscine • HCl is a standard α-2-adrenergic (AR) antagonist
CAS Number:
6211-32-1
Purity:
≥98%
Molecular Weight:
390.9
Molecular Formula:
C21H26N2O3 HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rauwolscine • HCl is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6 , and 0.6 nM at cloned human α2A-AR, , α2B-AR, and α2C-AR adrenoceptors respectively). Also exhibits partial agonist characteristics at 5-HT1A receptors.
References
1. Hieble, J.P., et al. 1995. J. Med. Chem. 38: 3415-3444. PMID: 7658428
2. Rump, L.C., et al. 1995. J. Cardiovasc. Pharmacol. 26: 462-470. PMID: 8583789
Appearance
:
Powder
Physical State
:
Solid
Solubility
:
Soluble in ethanol (5 mM), water (5 mM), and DMSO (25 mM).
Storage
:
Store at room temperature
Melting Point
:
288-290° C (dec.)
Boiling Point
:
543° C at 760 mmHg (Predicted)
Ki Data
:
α2A-adrenoceptor: Ki= 3.5 nM; α2B-adrenoceptor: Ki= 4.6 nM; α2C-adrenoceptor: Ki= 0.6 nM
pK Values
:
pKb: 8.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany
:
3
RTECS
:
ZG1035000
PubChem CID
:
MDL Number
:
MFCD06668052
EC Number
:
228-279-6
SMILES
:
COC(=O)[[email protected]@H]1[[email protected]](CC[[email protected]]2[[email protected]@H]1C[[email protected]]3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
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Rated 5 out of
5
by
MS from
Rauwolscine Hcl
Rauwolscine Hcl, is reported in many articles as an 2-adrenergic receptor antagonist and a stereo isomer of Yohimbine. -SCBT Publication Review
Date published: 2015-04-03