Rauwolscine • HCl is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6 , and 0.6 nM at cloned human α2A-AR, , α2B-AR, and α2C-AR adrenoceptors respectively). Also exhibits partial agonist characteristics at 5-HT1A receptors.
1. Hieble, J.P., et al. 1995. J. Med. Chem. 38: 3415-3444. PMID: 7658428 2. Rump, L.C., et al. 1995. J. Cardiovasc. Pharmacol. 26: 462-470. PMID: 8583789
Soluble in ethanol (5 mM), water (5 mM), and DMSO (25 mM).
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