raised against amino acids 1-55 mapping at the N-terminus of RARβ2 of human origin
Anti-RARβ/Retinoic Acid Receptor β Antibody (B-12) is recommended for detection of RARβ2 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-RARβ/Retinoic Acid Receptor β Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for Gel Supershift and ChIP applications (sc-514585 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of RARβ/Retinoic Acid Receptor β (B-12): sc-514585.
m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RARβ/Retinoic Acid Receptor β Antibody (B-12) for WB applications. These reagents are now offered in bundles with RARβ/Retinoic Acid Receptor β Antibody (B-12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RARβ2 Antibody (B-12) is a high quality monoclonal RAR beta 2 antibody (also designated RARB antibody, or retinoic acid receptor beta antibody) suitable for the detection of the RAR beta 2 protein of mouse, rat and human origin. RARβ2 Antibody (B-12) is available as both the non-conjugated anti-RAR beta 2 antibody form, as well as multiple conjugated forms of anti-RAR beta 2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families and thus modulate the effects of RA on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARα, RARβ and RARγ, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The human RARβ gene maps to chromosome 3p25-p21 and encodes two isoforms, RARβ1 and RARβ2. The RARβ2 isoform may act as a tumor suppressor gene by inducing apoptosis. This role for RARβ2 may explain the chemopreventive and therapeutic effects of retinoids. RARβ2 expression is diminished or lost completely during breast cancer progression. RARβ expression also decreases in over 50 percent of oral and lung premalignant lesions; loss of RARβ expression may contribute to carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences