Ranolazine DihydrochlorideA novel metabolic modulator

Ranolazine Dihydrochloride (CAS 95635-56-6)

Ranolazine Dihydrochloride | CAS 95635-56-6 is rated 5.0 out of 5 by 1.
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Synonym: (RS)-N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]piperazin-1-yl]acetamide
Application: A novel metabolic modulator
CAS Number: 95635-56-6
Molecular Weight: 500.47
Molecular Formula: C24H33N3O42HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ranolazine Dihydrochloride is a novel metabolic modulator and membrane stabilizer that is an antianginal and antiischaemic agent. This compound shifts myocardial energy metabolism away from free fatty acids and toward glucose as the substrate for production of adenosine triphosphate. Ranolazine Dihydrochloride is an activator of PDK.


References

Schofielf RS, Hill JA. Expert Opin Investig Drugs. 11:117-23 (2002). McCormack JG, Barr RL, Wolff AA et al. Circulation. 93:135-42 (1996). Lodge JP, Lam FT, Perry SL et al. Transplantation. 50:755-9 (1990).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml at 25° C), water (100 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
222-229.5° C (lit.)
Boiling Point :
624.1° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TK7845370
PubChem CID :
71279
Merck Index :
14: 8111
MDL Number :
MFCD03788770
SMILES :
Cl.Cl.COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1

Download SDS (MSDS)

Certificate of Analysis

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Ranolazine Dihydrochloride  Product Citations

See how others have used Ranolazine Dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26518873  2015. J. Biol. Chem. 290: 30910-23.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Allely MC; et al Allely MC; et al. (PubMed ID: 2331574) determined that Ranolazine Dihydrochloride blocked creatine kinase and lactate dehydrogenase in ischaemic induced baboons. -SCBT Publication Review
Date published: 2015-07-15
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