Ranolazine Dihydrochloride is a novel metabolic modulator and membrane stabilizer that is an antianginal and antiischaemic agent. This compound shifts myocardial energy metabolism away from free fatty acids and toward glucose as the substrate for production of adenosine triphosphate. Ranolazine Dihydrochloride is an activator of PDK.
Schofielf RS, Hill JA. Expert Opin Investig Drugs. 11:117-23 (2002). McCormack JG, Barr RL, Wolff AA et al. Circulation. 93:135-42 (1996). Lodge JP, Lam FT, Perry SL et al. Transplantation. 50:755-9 (1990).
Soluble in DMSO (100 mg/ml at 25° C), water (100 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Store at 4° C
222-229.5° C (lit.)
624.1° C at 760 mmHg (Predicted)
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Allely MC; et alAllely MC; et al. (PubMed ID: 2331574) determined that Ranolazine Dihydrochloride blocked creatine kinase and lactate dehydrogenase in ischaemic induced baboons. -SCBT Publication Review
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