Raltitrexed monohydrate

Raltitrexed monohydrate

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Synonym: L-Glutamic acid
Application: MF: C21H22N4O6S•H2O, MW: 476.50
Molecular Weight: 476.50
Molecular Formula: C21H22N4O6S•H2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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This is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, this prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.


References

1. Mauritz, R., et al. 2008. Cancer Chemother. Pharmacol. 62: 937-948. PMID: 18283461
2. Gangjee, A., et al. 2008. Anticancer Agents Med Chem. 8: 205-231. PMID: 18288923
3. Valentini, V., et al. 2008. Int. J. Radiat. Oncol. Biol. Phys. 70: 403-412. PMID: 17919844

Appearance :
Powder
Physical State :
Solid
Solubility :
H2O: ≥10 mg/mL: DMSO: ≥40 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III

Download SDS (MSDS)

Certificate of Analysis

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