Raf Kinase Inhibitor VAn inhibitor of Raf kinase

Raf Kinase Inhibitor V (CAS 918505-84-7)

Raf Kinase Inhibitor V | CAS 918505-84-7 is rated 4.0 out of 5 by 2.
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Synonym: PLX-4720
Application: An inhibitor of Raf kinase
CAS Number: 918505-84-7
Purity: ≥95%
Molecular Weight: 413.83
Molecular Formula: C17H14ClF2N3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Raf Kinase Inhibitor V is a cell-permeable azaindole compound that acts as a potent, ATP-site targeting and reversible inhibitor of Raf kinase with excellent selectivity over 64-other kinases. Raf Kinase Inhibitor V has been shown to block ERK phosphorylation, induce cell cycle arrest and apoptosis.


References

1. Tsai, J., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 3041-3046. PMID: 18287029

Physical State :
Solid
Solubility :
Soluble in DMSO (≥83 mg/ml), ethanol (<1 mg/ml), and water (<1 mg/ml).
Storage :
Store at 4° C
Density :
~1.55 g/cm3 (Predicted)
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
C-Raf-1Y340D/Y341D: IC50 = 6.7 nM; B-RafV600E: IC50 = 13 nM; BRK: IC50 = 130 nM; WT B-Raf: IC50 = 160 nM; 64 other kinases: IC50 = >1300 nM
pK Values :
pKa: 6.20 (Predicted), pKb: 0.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24180719
MDL Number :
MFCD14635203
SMILES :
CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F

Download SDS (MSDS)

Certificate of Analysis

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Raf Kinase Inhibitor V  Product Citations

See how others have used Raf Kinase Inhibitor V. Click on the entry to view the PubMed entry .

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PMID: # 29355586  Ma, L.|Li, K.|Guo, Y.|Sun, X.|Deng, H.|Li, K.|Feng, Q.|Li, S.| et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 560-571.

Citations 1 to 1 of 1 total
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Rated 4 out of 5 by from A decrease in expression of phosphorylated A decrease in expression of phosphorylated ERK was observed by WB after treating SK-MEL-28 cells with Raf Kinase Inhibitor V. -SCBT QC
Date published: 2015-04-17
Rated 4 out of 5 by from Product sc Product sc-222241A has been found to be a reversible inhibitor of Raf kinase and is highly selective, when compared to over 64 other kinases. ERK phosphorylation can be blocked by this compound as well, causing the cell to arrest and enter apoptosis (melanoma cells). -SCBT QC
Date published: 2015-04-01
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