R935788 (Fostamatinib disodium, R788)An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling

R935788 (Fostamatinib disodium, R788) (CAS 1025687-58-4)

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Synonym: R 788 sodium; FosD
Application: An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
CAS Number: 1025687-58-4
Purity: ≥98%
Molecular Weight: 624.42
Molecular Formula: C23H24FN6O9P.2Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (0.4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% CMC/0.25% Tween 80,pH6.5 (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.63 (Predicted)
IC50 :
Syk: IC50 = 41 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25008120
MDL Number :
MFCD15146370
SMILES :
CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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