R547 CAS: 741713-40-6
MF: C18H21F2N5O4S
MW: 441.45
A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4..

R547 (CAS 741713-40-6)

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Application: R547 is a selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4.
CAS Number: 741713-40-6
Purity: ≥99%
Molecular Weight: 441.45
Molecular Formula: C18H21F2N5O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1. R547 has shown antitumor activity, and may be promising for development of a potential treatment for solid tumors. The cyclin-dependent protein kinases are key regulators of cell cycle progression; altering the expression or activity of Cdk complexes can lead to aberrant cell cycle control, leading to unrestricted cell proliferation. CDK inhibitors have the potential to induce cell cycle arrest and apoptosis in cancer cells, and identifying small-molecule CDK inhibitors has been a major focus in cancer research.

Physical State :
Solid
Solubility :
Soluble in DMSO (60 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (< 1 mg/ml at 25 °C), and 1% hydroxyethyl cellulose/0.2% Tween 80 (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
226° C
Boiling Point :
~703.7° C at 760 mmHg
IC50 :
HCT116 cell line: IC50 = 80 nM
Ki Data :
CDK4/CyclinD1: Ki= 1 nM; CDK1/CyclinB: Ki= 2 nM; CDK2/CyclinE: Ki= 3 nM; PKA: Ki= > 5 µM; PKB: Ki= > 5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09970629
SMILES :
COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C

Download SDS (MSDS)

Certificate of Analysis

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