R406An IgE and IgG- mediated Fc signaling activation inhibitor

R406 (CAS 841290-81-1)

R406 | CAS 841290-81-1 is rated 5.0 out of 5 by 1.
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Synonym: N4-(2,2-dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine
Application: An IgE and IgG- mediated Fc signaling activation inhibitor
CAS Number: 841290-81-1
Purity: ≥98%
Molecular Weight: 628.63
Molecular Formula: C22H23FN6O5•C6H6O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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R406 is an inhibitor of IgE and IgG-mediated activation of Fc receptor signaling, stopping the production/release of LTC4, cytokines, and chemokines, including TNFα, IL-8, and GM-CSF. R406 inhibits phosphorylation of Syk substrate linker and blocks Syk-dependent T-cell and B-cell activation. R406 significantly induces chronic lymphocytic leukemia (CLL) cell apoptosis in nurse-like cell co-cultures and blocks CCL3 and CCL4 secretion by CLL cells in response to B-cell antigen receptor (Bcr) triggering. R406 is a potent inhibitor of platelet signaling and Flt-3/Flk-2.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml), and DMSO (126 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.62 (Predicted)
IC50 :
Syk: IC50 = 41 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11984591
MDL Number :
MFCD18385012
SMILES :
CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O

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R406  Product Citations

See how others have used R406. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 31340154  Ziegler, CGK.|Kim, J.|Piersanti, K.|Oyler-Yaniv, A.|Argyropoulos, KV.|van den Brink, MRM.|Palomba, ML.|Altan-Bonnet, N.|Altan-Bonnet, G.| et al. 2019. Cell Rep. 28: 923-937.e3.

PMID: # 31197205  Wang, WG.|Jiang, XN.|Sheng, D.|Sun, CB.|Lee, J.|Zhou, XY.|Li, XQ.| et al. 2019. Lab. Invest.

PMID: # 29728446  Hayashi, H.|Kaneko, R.|Demizu, S.|Akasaka, D.|Tayama, M.|Harada, T.|Irie, H.|Ogino, Y.|Fujino, N.|Sasaki, E.| et al. 2018. J. Pharmacol. Exp. Ther. 366: 84-95.

PMID: # 29868018  Dagher, Z.|Xu, S.|Negoro, PE.|Khan, NS.|Feldman, MB.|Reedy, JL.|Tam, JM.|Sykes, DB.|Mansour, MK.| et al. 2018. Front Immunol. 9: 1058.

PMID: # 28639315  Wang, WG.|Liu, ZB.|Jiang, XN.|Lee, J.|Zhou, XY.|Li, XQ.| et al. 2017. Histopathology. 71: 778-785.

PMID: # 27294852  Agustinho, DP. et al. 2016. Virulence. 0.

PMID: # 26829985  Khan, NS. et al. 2016. J. Immunol. 196: 2249-61.

PMID: # 26032420  Callaway, JB. et al. 2015. J. Biol. Chem. 290: 17306-20.

PMID: # 25970684  Wang, WG. et al. 2015. The American journal of surgical pathology. 39: 902-11.

PMID: # 26032420  Callaway, JB. et al. 2015. The Journal of biological chemistry. 290: 17306-20.

Citations 1 to 10 of 11 total
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Rated 5 out of 5 by from Koerber et al Koerber et al. (PubMed ID 26251761) used R406 to inhibit Sky in multiple myeloma cell lines AMO-1, U266 and RPMI8226. -SCBT Publication Review
Date published: 2015-04-04
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