R406 is an inhibitor of IgE and IgG-mediated activation of Fc receptor signaling, stopping the production/release of LTC4, cytokines, and chemokines, including TNFα, IL-8, and GM-CSF. R406 inhibits phosphorylation of Syk substrate linker and blocks Syk-dependent T-cell and B-cell activation. R406 significantly induces chronic lymphocytic leukemia (CLL) cell apoptosis in nurse-like cell co-cultures and blocks CCL3 and CCL4 secretion by CLL cells in response to B-cell antigen receptor (Bcr) triggering. R406 is a potent inhibitor of platelet signaling and Flt-3/Flk-2.
See how others have used R406. Click on the entry to view the PubMed entry .
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PMID: # 27294852 Agustinho, DP. et al. 2016. Virulence. 0.
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