Molecular structure of (R,S)-ATPA, CAS Number: 140158-50-5
(R,S)-ATPA (CAS 140158-50-5)
Alternate Names:
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid; 2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid; ATPA
Application:
(R,S)-ATPA is a potent and selective agonist of the GluR5 subtype of the kainate receptor
CAS Number:
140158-50-5
Molecular Weight:
228.25
Molecular Formula:
C10H16N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(R,S)-ATPA, short for (R,S)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propionic acid, is a compound of interest in the field of neurochemistry, where it is known to act as an agonist at the kainate class of glutamate receptors. In research focusing on neurological function, it is employed to study synaptic transmission, as these receptors play a role in excitatory neurotransmission in the central nervous system. It helps in mapping out the distribution of kainate receptors and provides insights into their physiological and pathological roles. (R,S)-ATPA also serves as useful in electrophysiological experiments designed to understand the kinetics and modulation of receptor channels. Beyond neuroscience, the compound′s interaction with glutamate receptors is utilized in research aimed at developing new materials and sensors capable of detecting the presence of neurotransmitters.
(R,S)-ATPA (CAS 140158-50-5) References
- Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7. | Cui, C. and Mayer, ML. 1999. J Neurosci. 19: 8281-91. PMID: 10493729
- [3H]ATPA: a high affinity ligand for GluR5 kainate receptors. | Hoo, K., et al. 1999. Neuropharmacology. 38: 1811-7. PMID: 10608276
- GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. | Paternain, AV., et al. 2000. J Neurosci. 20: 196-205. PMID: 10627597
- Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. | Kristensen, BW., et al. 2001. Brain Res. 917: 21-44. PMID: 11602227
- Characterisation of the effects of ATPA, a GLU(K5) receptor selective agonist, on excitatory synaptic transmission in area CA1 of rat hippocampal slices. | Clarke, VR. and Collingridge, GL. 2002. Neuropharmacology. 42: 889-902. PMID: 12069899
- Lesion of substantia nigra pars compacta by the GluR5 agonist ATPA. | Vivó, M., et al. 2002. Brain Res. 955: 104-14. PMID: 12419526
- The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. | Nielsen, MM., et al. 2003. Mol Pharmacol. 63: 19-25. PMID: 12488532
- The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures. | Kristensen, BW., et al. 2003. Brain Res. 973: 303-6. PMID: 12738075
- Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro. | Alt, A., et al. 2004. Neuropharmacology. 46: 793-806. PMID: 15033339
- Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices. | Clarke, VR. and Collingridge, GL. 2004. Neuropharmacology. 47: 363-72. PMID: 15275825
- Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development. | Sallert, M., et al. 2007. Neuropharmacology. 52: 1354-65. PMID: 17395219
- Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors. | Lv, Q., et al. 2012. Brain Res. 1456: 1-13. PMID: 22516108
- Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. | Lauridsen, J., et al. 1985. J Med Chem. 28: 668-72. PMID: 2859375
- A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. | Clarke, VR., et al. 1997. Nature. 389: 599-603. PMID: 9335499
- The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus. | Vignes, M., et al. 1998. Neuropharmacology. 37: 1269-77. PMID: 9849664
Activator of:
GluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R,S)-ATPA, 1 mg | sc-203232 | 1 mg | $50.00 | |||
(R,S)-ATPA, 5 mg | sc-203232A | 5 mg | $150.00 | |||
(R,S)-ATPA, 10 mg | sc-203232B | 10 mg | $209.00 | |||
(R,S)-ATPA, 50 mg | sc-203232C | 50 mg | $865.00 |