(R)-(+)-Propranolol hydrochlorideCAS: 5051-22-9
MF: C16H21NO2•HCl
MW: 295.81
A less active anantiomer the non-selective beta blocker propranolol.

(R)-(+)-Propranolol hydrochloride (CAS 5051-22-9)

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Synonym: (R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride; Propranolol HCl
Application: A less active anantiomer the non-selective beta blocker propranolol
CAS Number: 5051-22-9
Molecular Weight: 295.81
Molecular Formula: C16H21NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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(R)-(+)-Propranolol hydrochloride is the less active enantiomer of propranolol hydrochloride. (R)-(+)-Propranolol hydrochloride is an inhibitor of AR.


References

1. Bond, P.A. 1967. Nature. 213: 721. PMID: 6031788
2. Barrett, A.M., et al. 1968. Br. J. Pharmacol. 34: 43-55. PMID: 19108278

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/ml), DMSO (<14.5 mg/ml), water (50 mg/ml), and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (8.0 mg/ml).
Storage :
Store at room temperature
Melting Point :
196-198° C (lit.)
Boiling Point :
434.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.58 (Predicted)
Optical Activity :
α20/D +23.6°, c = 1 in ethanol
IC50 :
β2-AR: IC50 = 76 nM (human); β1-AR: IC50 = 370 nM (human); SR-2B: IC50 = 438 nM (human); ST: IC50 = 612 nM (human); Sigma opioid receptor: IC50 = 3.97 µM (human)
Ki Data :
β2-AR: Ki= 52 nM (human); β1-AR: Ki= 214 nM (human); SR-2B: Ki= 279 nM (human); ST: Ki= 325 nM (human); Sigma opioid receptor: Ki= 1.67 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UB7505000
PubChem CID :
66366
MDL Number :
MFCD00064546
EC Number :
235-961-7
Beilstein Registry :
5780490
SMILES :
CC(C)NC[[email protected]@H](COC1=CC=CC2=CC=CC=C21)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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