(R)-(+)-m-Nitrobiphenyline oxalate (CAS 945618-97-3)
Application:
(R)-(+)-m-Nitrobiphenyline oxalate is an α2C-AR agonist which inhibits cAMP accumulation
CAS Number:
945618-97-3
Purity:
≥99%
Molecular Weight:
401.37
Molecular Formula:
C17H17N3O3 C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
(R)-(+)-m-Nitrobiphenyline oxalate is an α2C-AR (adrenoceptor) agonist that potently inhibits cAMP accumulation in CHO cells (EC50 = 38 nM).It behaves as an antagonist at α2A-AR and α2B-AR (pKb = 7.11 and 6.07 respectively).
References
1. Crassous, Pierre-Antoine., et al., 2007. Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist. Journal of medicinal chemistry. 50(16): 3964-8. PMID: 17630725
Physical State
:
Solid
Solubility
:
Soluble in DMSO (75 mM), and ethanol (5 mM).
Storage
:
Store at 4° C
Melting Point
:
209-210° C
Refractive Index
:
n20D 1.63 (Predicted)
Optical Activity
:
α20/D +24.6°, c = 1 in methanol
IC50
:
α 2c AR: EC5050 = 10 nM (human)
Ki Data
:
α 2a AR: Ki= 81.28 nM (human); α 2c AR: Ki= 0.26 µM (human); α 2b AR: Ki= 0.74 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
PubChem CID
:
MDL Number
:
MFCD18086850
SMILES
:
C[[email protected]](C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-].C(=O)(C(=O)O)O
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents