(R)-(+)-m-Nitrobiphenyline oxalate CAS: 945618-97-3
MF: C17H17N3O3 C2H2O4
MW: 401.37
An α2C-AR agonist which inhibits cAMP accumulation.

(R)-(+)-m-Nitrobiphenyline oxalate (CAS 945618-97-3)

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Application: (R)-(+)-m-Nitrobiphenyline oxalate is an α2C-AR agonist which inhibits cAMP accumulation
CAS Number: 945618-97-3
Purity: ≥99%
Molecular Weight: 401.37
Molecular Formula: C17H17N3O3 C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(R)-(+)-m-Nitrobiphenyline oxalate is an α2C-AR (adrenoceptor) agonist that potently inhibits cAMP accumulation in CHO cells (EC50 = 38 nM).It behaves as an antagonist at α2A-AR and α2B-AR (pKb = 7.11 and 6.07 respectively).


References

1. Crassous, Pierre-Antoine., et al., 2007. Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist. Journal of medicinal chemistry. 50(16): 3964-8. PMID: 17630725

Physical State :
Solid
Solubility :
Soluble in DMSO (75 mM), and ethanol (5 mM).
Storage :
Store at 4° C
Melting Point :
209-210° C
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D +24.6°, c = 1 in methanol
IC50 :
α 2c AR: EC5050 = 10 nM (human)
Ki Data :
α 2a AR: Ki= 81.28 nM (human); α 2c AR: Ki= 0.26 µM (human); α 2b AR: Ki= 0.74 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD18086850
SMILES :
C[[email protected]](C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-].C(=O)(C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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