(R)-LisofyllineAn immunomodulator and metabolite of Pentoxifyline, it inhibits phosphatidic acid production

(R)-Lisofylline (CAS 100324-81-0)

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Application: An immunomodulator and metabolite of Pentoxifyline, it inhibits phosphatidic acid production
CAS Number: 100324-81-0
Molecular Weight: 280.32
Molecular Formula: C13H20N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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(R)-Lisofylline is an immunomodulator and a major metabolite of Pentoxifylline and Methylxanthine. (R)-Lisofylline inhibits production of phosphatidic acid during the inflammatory response.


References

1. Clarke, E., et al. 1996. Cancer Res. 56: 105-112. PMID: 8548748
2. Itani, S.I., et al. 2001. Metab. Clin. Exp. 50: 553-557. PMID: 11319716
3. Itani, S.I., et al. 2002. Diabetes. 51: 2005-2011. PMID: 12086926
4. Yu, C., et al. 2002. J. Biol. Chem. 277: 50230-50236. PMID: 12006582

Physical State :
Solid
Solubility :
Soluble in ethanol (~25 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), chloroform, and methanol.
Storage :
Store at -20° C
Melting Point :
105-107° C
Boiling Point :
511.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -6.26°, c = 1 in methanol
pK Values :
pKb: 0.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
501254
MDL Number :
MFCD00867573
SMILES :
C[C@H](CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O

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Certificate of Analysis

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