R-848An immune response modifier and TLR7 and TLR8 activator

R-848 (CAS 144875-48-9)

R-848 | CAS 144875-48-9 is rated 5.0 out of 5 by 1.
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Synonym: Resiquimod; S 28463
Application: An immune response modifier and TLR7 and TLR8 activator
CAS Number: 144875-48-9
Purity: ≥98%
Molecular Weight: 314.39
Molecular Formula: C17H22N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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R-848 is a low-molecular-weight immune response modifier. It is reported to possess anti-tumor and anti-viral properties. It has been shown to mimic pathogen associated molecular patterns, activating immune cells through TLR7 and TLR8 (Toll-like receptors 7 and 8). It can induce interferon-alpha sythesis as well as the synthesis of other cytokines in various cell types. Evidence suggests its efficacy again herpes simples virus (HSV) type 2 in vivo. It has been shown to up-regulate IFN-γ production and proliferation by memory CD4+ T cells. It has also been shown to mimic CD40-induced B cell activation. R-848 is an activator of TLR7 and TLR8.


References

1. Bishop, G.A., et al. 2001. Cell. Immunol. 208: 9-17. PMID: 11277614
2. Hemmi, H., et al. 2002. Nat. Immunol. 3: 196-200. PMID: 11812998
3. Wu, J.J., et al. 2004. Antiviral Res. 64 79-83. PMID: 15498602
4. Caron, G., et al. 2005. J. Immunol. 175: 1551-1557. PMID: 16034093

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (50 mM), 100% or 5% methanol, and dichloromethane. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
166° C
Boiling Point :
~553.59° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Hepatitis C virus: EC5050 = 24 nM; TLR7 : EC5050 = 0.26 µM (human); TLR8 : EC5050 = 6.4 µM (human)
pK Values :
pKb: 6.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NJ5911320
PubChem CID :
159603
MDL Number :
MFCD00937759
Beilstein Registry :
9792901
SMILES :
CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N

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Certificate of Analysis

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R-848  Product Citations

See how others have used R-848. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28432455  Moreno Ayala, MA. et al. 2017. J. Cancer Res. Clin. Oncol.

PMID: # 27753084  Ren, JP. et al. 2017. Immunology. 150: 213-220.

PMID: # 27004559  Ren, JP. et al. 2016. J. Viral Hepat. 23: 755-66.

PMID: # 27149428  Ren, JP. et al. 2016. Immunology.

PMID: # 26959508  Wang, L.|Zhao, J.|Ren, JP.|Wu, XY.|Morrison, ZD.|Elgazzar, MA.|Ning, SB.|Moorman, JP.|Yao, ZQ.| et al. 2016. AIDS. 30: 1521-1531.

PMID: # 14517278  Fitzgerald, K.A. et al. 2003. The Journal of experimental medicine. 198: 1043-55.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Fitzgerald Fitzgerald, KA. et al. (PubMed 14517278) used R-848, a selective agonsit for TLR7 and TLR8, to elucidate the LPS-TLR4 signaling pathway. With the use of R-848 they found that the TLR4 pathway requires TIR-domain-containing adapter-inducing interferon- , TRIF, related adaptor molecule (TRAM), myeloid differentiation factor 88, and MyD88 adaptor-like protein (Mal)/TIRAP. -SCBT Publication Review
Date published: 2015-05-05
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