R-848 is a low-molecular-weight immune response modifier. It is reported to possess anti-tumor and anti-viral properties. It has been shown to mimic pathogen associated molecular patterns, activating immune cells through TLR7 and TLR8 (Toll-like receptors 7 and 8). It can induce interferon-alpha sythesis as well as the synthesis of other cytokines in various cell types. Evidence suggests its efficacy again herpes simples virus (HSV) type 2 in vivo. It has been shown to up-regulate IFN-γ production and proliferation by memory CD4+ T cells. It has also been shown to mimic CD40-induced B cell activation. R-848 is an activator of TLR7 and TLR8.
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See how others have used R-848. Click on the entry to view the PubMed entry .
PMID: # 28432455 Moreno Ayala, MA. et al. 2017. J. Cancer Res. Clin. Oncol.
PMID: # 27753084 Ren, JP. et al. 2017. Immunology. 150: 213-220.
PMID: # 27004559 Ren, JP. et al. 2016. J. Viral Hepat. 23: 755-66.
PMID: # 27149428 Ren, JP. et al. 2016. Immunology.
PMID: # 26959508 Wang, L.|Zhao, J.|Ren, JP.|Wu, XY.|Morrison, ZD.|Elgazzar, MA.|Ning, SB.|Moorman, JP.|Yao, ZQ.| et al. 2016. AIDS. 30: 1521-1531.
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