R 59-022 potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. R 59-022 inhibits DGK (diacylglycerol kinase, IC50 = 2.8 μM) without affecting phosphodiesterase or phosphatidylinositol kinase. R 59-022 is a weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.
Goin, M., et al. 1993. FEBS Lett. 316, 68. Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418. de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
Soluble in ethanol (20 mM), DMSO (50 mM), water (3 mg/l), acetone (2.6 g/100ml), N,N-DMF (7.5 g/100ml), methanol (1.7 g/100ml), dichloromethane (>50 g/100ml), 0.1M HCl(slightly), 0.1M NaOH(slightly), and ethyl acetate.
Store at -20° C
259.56° C (Predicted)
619.78° C at 760 mmHg (Predicted)
1.26 g/cm3 (Predicted)
n20D 1.65 (Predicted)
diacylglycerol kinase: IC50 = 2.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MartinezMartinez, K. et al. (PubMed 23264678) reported that diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. -SCBT Publication Review
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