R 59-022An inhibitor of DGK and serotonin

R 59-022 (CAS 93076-89-2)

R 59-022 | CAS 93076-89-2 is rated 5.0 out of 5 by 1.
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Synonym: Diacylglycerol Kinase Inhibitor I
Application: An inhibitor of DGK and serotonin
CAS Number: 93076-89-2
Purity: ≥98%
Molecular Weight: 459.58
Molecular Formula: C27H26FN3OS
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

R 59-022 potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. R 59-022 inhibits DGK (diacylglycerol kinase, IC50 = 2.8 μM) without affecting phosphodiesterase or phosphatidylinositol kinase. R 59-022 is a weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.


References

Goin, M., et al. 1993. FEBS Lett. 316, 68. Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418. de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.

Physical State :
Solid
Solubility :
Soluble in ethanol (20 mM), DMSO (50 mM), water (3 mg/l), acetone (2.6 g/100ml), N,N-DMF (7.5 g/100ml), methanol (1.7 g/100ml), dichloromethane (>50 g/100ml), 0.1M HCl(slightly), 0.1M NaOH(slightly), and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
259.56° C (Predicted)
Boiling Point :
619.78° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
diacylglycerol kinase: IC50 = 2.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3012
MDL Number :
MFCD00055114
SMILES :
CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Martinez Martinez, K. et al. (PubMed 23264678) reported that diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. -SCBT Publication Review
Date published: 2015-07-07
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