R-(+)-DIOAAn inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system

R-(+)-DIOA (CAS 81166-47-4)

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Synonym: R-(+)-Butylindazone; (Dihydroindenyl)oxy alkanoic acid
Application: An inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system
CAS Number: 81166-47-4
Purity: ≥98%
Molecular Weight: 399.31
Molecular Formula: C20H24Cl2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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R-(+)-DIOA acts as an inhibitor of the K+/Cl--cotransporter (KCC) that does not affect the bumetanide-sensitive Na+/K+/Cl--cotransport system.


References

The significance of the relative effects of loop diuretics and anti-brain edema agents on the Na+,K+,Cl- cotransport system and the Cl-/NaCO3- anion exchanger: R.P. Garay, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 334, 202 (1986) Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl- ]-cotransport system: R.P. Garay, et al.; Mol. Pharmacol. 33, 696 (1988)

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml), 0.1 M NaOH, and ethanol. Insoluble in water(<0.11 mg/mL), and 0.1 M HCl.
Storage :
Store at -20° C
Melting Point :
175-176° C
Boiling Point :
562.15° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α27/D +18.1°, c = 0.7 in methanol
IC50 :
Plasmodium falciparum: IC50 = 10 µM; Felis catus: IC50 = 50 µM
pK Values :
pKa: 2.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10386195
MDL Number :
MFCD00069261
SMILES :
CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3

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Certificate of Analysis

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R-(+)-DIOA  Product Citations

See how others have used R-(+)-DIOA. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27639636  Huang, YJ. et al. 2016. Exp. Neurol. 285: 82-95.

Citations 1 to 1 of 1 total

Dear Santa Cruz, How long is DIOA (sc-203230A) stable in DMSO when keept at -20C? Thanks Annette

Asked by: abs1
Thank you for your question. For this chemical, R-(+)-DIOA: sc-203230, it is recommended to use solutions the same day they are made. If needed, you can freeze tightly sealed aliquots for up to a month. The aliquot should thaw at room temp for at least an hour. Multiple freeze and thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2017-05-05
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