R-(+)-Baclofen hydrochlorideA seelctive GABAB receptor agonist

R-(+)-Baclofen hydrochloride (CAS 63701-55-3)

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Synonym: CG15274; R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl; R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
Application: A seelctive GABAB receptor agonist
CAS Number: 63701-55-3
Purity: ≥98%
Molecular Weight: 250.12
Molecular Formula: C10H12ClNO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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R-(+)-Baclofen hydrochloride is the hydrochloride salt preparation of the 3-(p-chlorophenyl)-4-aminobutanoic acid R-(+) enantiomer, an derivative of GABA and a selective agonist of the GABAB receptor. The R-(+)-Baclofen isomer is described to be 4.2-9.2-fold as effective as the S-(-) isomer.


References

1. Witczuk, B., et al. 1980. Pol J Pharmacol Pharm. 32: 187-196. PMID: 7454623
2. Falch, E., et al. 1986. J. Neurochem. 47: 898-903. PMID: 3016189
3. Hong, Y.G. and Henry, J.L. 1991. Eur. J. Pharmacol. 196: 267-275. PMID: 1654254
4. Frankowska, M., et al. 2007. Pharmacol Rep. 59: 645-655. PMID: 18195453

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml), water (26 mg/ml), and dilute aqueous base.
Storage :
Store at 4° C
Melting Point :
220-222° C (Predicted)
Boiling Point :
364.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.58
Optical Activity :
α28/D +3.8°, c = 0.9 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MW5084350
PubChem CID :
44601
Merck Index :
14: 937
MDL Number :
MFCD00078579
SMILES :
Cl.NC[C@H](CC(O)=O)C1=CC=C(Cl)C=C1

Download SDS (MSDS)

Certificate of Analysis

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Is Baclofen hydrochloride made under GMP conditions? Is it suitable for using in a FDA approvable product?gopi

Asked by: Gopi
Thank you for your inquiry. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. They are intended only for research applications and are not for pharmaceutical, therapeutic, or diagnostic use.
Answered by: Technical Service
Date published: 2016-11-02
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