R-(+)-Baclofen hydrochloride is the hydrochloride salt preparation of the 3-(p-chlorophenyl)-4-aminobutanoic acid R-(+) enantiomer, an derivative of GABA and a selective agonist of the GABAB receptor. The R-(+)-Baclofen isomer is described to be 4.2-9.2-fold as effective as the S-(-) isomer.
1. Witczuk, B., et al. 1980. Pol J Pharmacol Pharm. 32: 187-196. PMID: 7454623 2. Falch, E., et al. 1986. J. Neurochem. 47: 898-903. PMID: 3016189 3. Hong, Y.G. and Henry, J.L. 1991. Eur. J. Pharmacol. 196: 267-275. PMID: 1654254 4. Frankowska, M., et al. 2007. Pharmacol Rep. 59: 645-655. PMID: 18195453
Soluble in DMSO (>20 mg/ml), water (26 mg/ml), and dilute aqueous base.
Store at 4° C
220-222° C (Predicted)
364.3° C at 760 mmHg (Predicted)
α28/D +3.8°, c = 0.9 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Is Baclofen hydrochloride made under GMP conditions? Is it suitable for using in a FDA approvable product?gopi
Asked by: Gopi
Thank you for your inquiry. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. They are intended only for research applications and are not for pharmaceutical, therapeutic, or diagnostic use.
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